I-SARM SR9011 I-Pharmaceutical Raw Powder Yokuthuthukisa Ukukhuthazela Ukuzivocavoca CAS 1379686-30-2

I-SARM SR9011 I-Pharmaceutical Raw Powder Yokuthuthukisa Ukukhuthazela Ukuzivivinya CAS 1379686-30-2 Isithombe Esifakiwe

incazelo emfushane:

Incazelo Yomkhiqizo Eningiliziwe

Igama Lomkhiqizo:I-SR9011
Imikhiqizo Ehlobene:I-SR9009
I-CAS:1379686-29-9
Ukubukeka:Impushana Emhlophe
Ukusetshenziswa:Ukwakha Kwemisipha
Indlela Yokuthumela:EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
Ukukhanya Okuphezulu:sarms bodybuilding supplements, sarms steroids

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Imininingwane Esheshayo ye-SR9011

Cas No 1379686-29-9
Omqondofana 3-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Ifomula C23H31ClN4O3S
Isisindo se-Molucelar 479.03524

I-SR9011Incazelo

I-SR9011 iyi-monomer ye-methacrylate esebenza kathathu ehlinzeka ngokunamathela okukhethekile ensimbi.
ama-substrates.

I-SR9011 iyanconywa ukuthi isetshenziswe kuma-peroxide elashiwe, ama-sealant, nama-plastisols asekelwe ku-PVC.
Amazinga okusetshenziswa ka-5% kuya ku-10% ngesisindo ayanconywa.

I-SR9011 iyi-REV-ERB enamandla futhi ethize yokwenziwa.Iphinde ibe nokuchayeka okuhle kwe-vivo plasma/ubuchopho.
Ama-nuclear receptors REV-ERB-α kanye ne-REV-ERB-β adlala indima ebalulekile ekulawuleni inkulumo.
amaprotheni ewashi ayisisekelo, isigqi sokushayela emsebenzini kanye ne-metabolism.Ukuphathwa kwezinguquko ze-SR9011
ukuziphatha kwe-circadian kanye nephethini ye-circadian ye-core clock gene expression ku-hypothalami yamagundane.
Iphethini ye-circadian expression yohlu lwezakhi zofuzo ze-metabolic esibindini, emisipha yamathambo kanye
Izicubu ze-adipose nazo zashintshwa, okuholele ekwenyukeni kwezindleko zamandla.Ukwelashwa kokudla okubangelwa ukudla
amagundane akhuluphele ane-SR9011 ehle ukukhuluphala ngokunciphisa inqwaba yamafutha futhi athuthuka ngokuphawulekayo i-dyslipidaemia kanye ne-hyperglycemia.Le miphumela ikhombisa ukuthi ama-synthetic REV-ERB ligands aqondiswe ngokwemithi
isigqi se-circadian singase sibe nenzuzo ekwelapheni ukuphazamiseka kokulala kanye nezifo ze-metabolic.

Ungayisebenzisa kanjani i-SR9011?

I-In vitro: I-SR9011 isetshenziswe ekugxilweni kwe-5-10 μM ku-vitro nasezivivinyweni zamaselula.
Ku-vivo: Ukuphathwa kwe-IP ye-SR9011 kwasetshenziswa ku-100 mg/kg kanye noma kabili ngosuku nge-12-30
izinsuku kumamodeli amagundane ahlukene.

Ukuhlanganiswa kwe-SR9009 kanye ne-SR9011

Amakhompiyutha ahlanganiswa nge-amination enciphisayo ye-5-nitro-2-thiophenecarboxaldehyde ene-4-chlorobenzylamine kanye ne-sodium triacetoxyborohydride iveze i-amine yesibili.I-amination yesibili yokunciphisa nge-1-Boc-pyrrolidine-3-carboxaldehyde iveze i-amine ephakeme.Le nhlanganisela yaphathwa nge-trifluoroacetic acid ukuze isuse iqembu lokuvikela i-Boc, bese isabela nge-ethyl chloroformate (SR9009) noma i-pentyl isocyanate (SR9011) ukunikeza imikhiqizo efunekayo.

I-SR9011I-COA

Into	Ukucaciswa	Umphumela
Ukubukeka	Impushana engenaphunga, cishe emhlophe noma emhlophe	dlula
I-Identification	Isikhathi sokugcina sesiqongo esikhulu ngu qinisekisa ku-RS	dlula
Ukulahlekelwa Ekumisweni	Hhayi ngaphezu kuka-0.5%	0.33%
I-Assay(HPLC)	Hhayi ngaphansi kuka-99.0%	99.59%
Izinsalela zokubasa	Hhayi ngaphezu kuka-0.1%	dlula
Insimbi enzima	Hhayi ngaphezu kuka-20 ppm	dlula