i-pharmaceutical intermediate 99% ubumsulwa powder CAS 86386-73-4 Fluconazol
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Ulwazi Oluyisisekelo
I-Fluconazole-D4 ibonakala iyimpushana ecwebezelayo emhlophe ukuya kokuphuzi-mhlophe futhi inephunga elincane elinokunambitheka okubabayo.
Incibilika kalula ku-glacial acetic acid, i-methanol noma i-ethanol, ayincibiliki kalula emanzini futhi cishe ayincibiliki ku-ether nendawo yokuncibilika ingu-137~141.6 ℃, noma indawo encibilikayo ingu-138~140 ℃ (etholakala ku-ethyl acetate-hexane).
Ukusetshenziswa
Lo mkhiqizo ungowomuthi we-fluorinated triazole antifungal kanye ne-antifungal spectrum efana ne-ketoconazole kodwa umsebenzi we-antifungal uphakeme kune-ketoconazole.
Indlela yokusebenza kwayo iwukuvinjwa kwengxenye ebalulekile ye-fungus cell membrane, i-ergosterol biosynthesis enzyme, ukuvimbela ukwakheka kwe-ergosterol kanye nokuphula ubuqotho bodonga lwamaseli fungal, kuqhubeke kuvimbela ukukhula nokuzala kwawo.
Umkhiqizo unomsebenzi onamandla we-antifungal ngokumelene ne-Candida albicans, i-Microsporum canis, i-Cryptococcus neoformans, i-histoplasma capsulatum ne-epidermophyton.
Chemical Properties
I-Fluconazole-D4 Iqinile Okumhlophe kuya kokumhlophe
Isebenzisa Ilebula I-Fluconazole (F421000).Isetshenziswa njenge-antifungal.
Isebenzisa i-anticholinergic
I-Fluconazole-D4 isetshenziselwa ukwelapha izifo zesikhunta.
Isebenzisa i-A triazole broad-spectrum antifungal agent.
Izinkomba
I-Fluconazole (i-Diflucan) ingase imunce kangcono futhi kungenzeka ibe ne-hepatotoxic encane kune-ketoconazole, kodwa ibiza kakhulu, ukucatshangelwa okubalulekile uma kubhekwa ubude obudingekayo bokwelapha ezifweni eziningi zesikhunta esikhunta.