Izithasiselo eziningana ezivamile zokulwa nokuguga

Isihloko sokulwa nokuguga sesithandwa kakhulu eminyakeni yamuva nje, kanti izifundo ezahlukene zivela ngokungapheli.
Njalo nje, iqembu elithile locwaningo lithola into evimbela ukuguga engasisiza siphile iminyaka eyikhulu.
Thina bantu sinomkhawulo wokuphila iminyaka engu-150, ngoba ama-telomere afinyeza kancane njalo ngemva kweminyaka emibili kuya kwemithathu, futhi amangqamuzana angahlukana izikhathi ezingaba ngu-50, kusho u-Hafrick we-telomere Theory.
Kukhona futhi abanye ochwepheshe abanethemba lokuthi: umuntu wokuqala ophile iminyaka eyi-1000, uzelwe, emhlabeni wethu, kungaba nguwe oh.
Ngokuthuthuka kwebhayoloji ye-biomolecular, ngolunye usuku singathola into ewumlingo ezosisiza siphile isikhathi eside.
Ngakho-ke, phila unempilo, sebenza kanzima ukuze wenze imali, futhi ulinde ubuchwepheshe buvuthwe ngolunye usuku, mhlawumbe, ungaphila impilo ende ngempela.
Namuhla, ngizokwethula ezinye zezithako ezithembisayo zokulwa nokuguga ezibonwayo, futhi sibheke ezimbalwa ozibonile.

1. I-Epitalon

I-Epitalon iyi-peptide yokwenziwa yokulwa nokuguga, ekhiqizwa ochungechungeni lwe-amino acid i-alanine-glutamine-asparagine-glycine, ekhulisa umsebenzi we-telomerase emzimbeni ukusiza ukunciphisa izinga lokuguga.

Ama-telomere afana nezigqoko eziqinile ezivikela i-DNA.Ama-chromosome amaningi emzimbeni anama-telomere kuzo zombili iziphetho;Umsebenzi oyinhloko we-telomerase ukusiza ukugcina ubude be-telomeres emzimbeni.

Ezinye izifo zihlotshaniswa nama-telomere amafushane, okuholela ekugugeni ngokushesha;I-Epitalon ingasetshenziselwa ukwelapha izifo ezibangela ukuguga ngaphambi kwesikhathi, njenge-Bloom syndrome kanye ne-Werner syndrome.

I-Epitalon iphinde isize ukunciphisa ingozi yezifo ezihlobene nokushoda kwe-telomerase, njengesifo sikashukela, ngoba ukukhiqizwa kwe-insulin kuvinjelwa ukushoda kwe-telomerase.

I-peptide ingase futhi ibe nomthelela omuhle empilweni yenhliziyo futhi ingasiza ekuvimbeleni isifo senhliziyo;Ososayensi bacwaninga amandla ayo ekwelapheni izimila.

2: I-curcumin

I-Turmeric iyisithako sokudla samaNdiya kakhulu, futhi i-curcumin iyisithako esisebenzayo esifundwe kakhulu ku-turmeric, enezakhiwo eziqinile zokulwa nokuvuvukala kanye ne-antioxidant.

Ucwaningo lubonise ukuthi i-curcumin yenza kusebenze ama-sirtuins (deacetylases) kanye ne-AMPK(AMP-activated protein kinase), esiza ukubambezela ukuguga kwamaseli futhi andise ukuphila.

Ngaphezu kwalokho, i-curcumin iye yaboniswa ukulwa nokulimala kwamangqamuzana futhi yandisa kakhulu isikhathi sokuphila sezimpukane zezithelo, izikelemu, namagundane;Kungase futhi kubambezele ukuqala kwezifo ezihlobene neminyaka futhi kunciphise izimpawu zezifo ezihlobene neminyaka

3: i-cannabinoid

Izithako ezisebenzayo ze-cannabis, ezaziwa ngokuhlanganyela njengama-cannabinoids, ziyiqembu lama-terpenoid phenolic compounds, adume kakhulu kuwo i-tetrahydrocannabinol (THC) kanye ne-cannabidiol (CBD).

I-CBD ingalwa nama-radicals mahhala kumaseli esikhumba, isebenze njenge-antioxidant ne-anti-aging agent.Ivame ukungezwa emikhiqizweni yokunakekelwa kwesikhumba futhi ivame ukusetshenziselwa ukukhulula ubuhlungu obungapheli, ngemiphumela emihle

4: i-spermidine

I-Spermidine iyingxenye yemvelo yesidoda, futhi imizimba yethu (kokubili owesilisa nowesifazane) ikhiqiza cishe ingxenye yesithathu yayo, kanti okunye kuvela ekudleni kwethu.

Imithombo yawo yokudla ihlanganisa: ushizi osekhulile, amakhowe, i-natto, upelepele oluhlaza, igciwane likakolweni, ukholifulawa, i-broccoli, njll.

Abantu base-Asia banamazinga aphezulu e-arginous acid ekudleni kwabo, okungase kuhlobane nempilo yabo ende.

Ucwaningo nge-spermidine belukhula eminyakeni yamuva nje, futhi kutholakale ukuthi linemiphumela elandelayo:

Nweba isikhathi sempilo enempilo;

Ukuthuthukisa izinga lokuqonda kwabantu asebekhulile;

Umphumela we-Neuroprotective;

Ukunciphisa ukufa okuyimbangela;

Umfutho wegazi ophansi;

Yenza i-autophagy kanye nokubambezeleka kwe-senescence;

Kwenza izinwele zikhule ngokushesha nezinzipho zibe namandla.

5: umzimba we-ketone

Esinye sezizathu eziyinhloko ukuthi ukudla kwe-ketogenic kuthandwa ukulahlekelwa isisindo nokucaca kwengqondo.

Lapho umzimba uqala ukushisa amafutha omzimba, ukhiqiza imizimba ye-ketone, enikeza amandla ahlanzekile ebuchosheni futhi ithuthukise ukusebenza kwayo.

Ama-Ketones anezindawo zokulwa nokuguga, futhi ucwaningo luye lwathola ukuthi i-BHB (i-beta-hydroxybutyric acid) ingakhuthaza ukuhlukana kwamangqamuzana, ivimbele ukuguga kwamangqamuzana, futhi igcine imithambo yegazi nobuchopho busha.

Umzimba ungakhiqiza imizimba ye-keto ngokugwema ama-carbohydrate, noma ungathatha izithasiselo ze-keto zangaphandle ukusheshisa inqubo futhi unciphise ubuhlungu benguquko, okwaziwa ngokuthi “i-keto flu.”

Izidlo ze-Ketogenic, noma ukuthatha izithasiselo ze-keto zangaphandle, kunganciphisa ukuguga, kuthuthukise ukusebenza kwengqondo, futhi kusize ukunqanda izifo ze-neurodegenerative njenge-Alzheimer's.

6: Dasatinib

Njengoba sikhula, amanye amangqamuzana ethu ayavika amasosha omzimba.Lawa maseli “asaphila” awakwenzi obekufanele akwenze, kodwa asashisa amandla.

Amaseli anjalo “konke ukudla nokungasebenzi”, aziwa nangokuthi “amaseli e-zombie”, noma amaseli enzwa, anqwabelana ngokuhamba kwesikhathi, okwenza umzimba usebenze kancane.

Ukuzila ukudla, ukuvivinya umzimba nezinye izindlela zokuphila ezinempilo kubangela i-autophagy, ehlanza amaseli e-zombie.

I-Dasatinib, isidakamizwa se-chemotherapy esisetshenziswa ekwelapheni i-leukemia, ingaphinda isuse ngempumelelo amangqamuzana amafutha aguga futhi inciphise ukugcinwa kwama-cytokines abangela ukuvuvukala ezicubu ze-adipose zomzimba.

Umuthi wokuqala we-Senolytics ozotholwa, umuthi osula ngokukhetha amaseli ayisitho somzimba ngokuphazamisa izindlela zokubonisa amaseli eseli, sikhubaze okwesikhashana i-SCAps (izindlela zokulwa ne-apoptotic).

Izinto ezingasusa amaseli e-senescent zihlanganisa i-PCC1 evela ku-Chinese Academy of Sciences, kanye nezinye izithako ezifana ne-quercetin.