Umkhiqizo Oshisayo I-Semaglutide CAS 910463-68-2 Hot

Isingeniso ku-Somaglutide

I-Somaglutide isizukulwane esisha se-GLP-1 (glucagon efana ne-peptide-1) analog eyakhiwe nguDaminol noNovoNordisk.I-Somaglutide iyindlela yokulinganisa isikhathi eside eyakhiwe ngokusekelwe esakhiweni esiyisisekelo se-Lilalutide, esinomthelela ongcono ekwelapheni uhlobo lwesifo sikashukela sohlobo 2.I-Novo Nordisk isiqedile izifundo ze-6 PChemicalbookbaseIIIa ngomjovo we-Somaglutide, futhi yahambisa isicelo esisha sokubhaliswa kwezidakamizwa ngomjovo wamasonto onke we-Somaglutide ku-US Food and Drug Administration (FDA) ngoDisemba 5, 2016, kanye nesicelo sokugunyazwa kokumaketha (MAA) ukuze Isidakamizwa saseYurophu Aukuphatha (EMA).Ngakolunye uhlangothi, ukulungiswa komlomo kanye kwansuku zonke kwe-Somaglutide okwamanje kusigaba somtholampilo III.

Ukusetshenziswa

I-Somaglutide iyifomu lomthamo osebenza isikhathi eside elakhiwe ngokususelwa esakhiweni esiyisisekelo se-liraglutide, esinomphumela ongcono ekwelapheni uhlobo 2 sikashukela.

Ucwaningo

I-Semeglutide iyi-analog entsha ye-GLP-1 ejovwa ngaphansi kwesikhumba kanye ngesonto.I-Somaglutide iyi-analog ye-GLP-1 esebenza isikhathi eside eyakhiwe yi-Novo Nordisk umjovo wesikhathi esisodwa/w ongaphansi kwesikhumba.Uma kuqhathaniswa ne-liraglutide, i-Somaglutide inochungechunge lwamafutha olude kanye ne-hydrophobicity eyandayo.Kodwa-ke, i-Somaglutide iguqulwa nge-PEG ye-chain short, futhi i-hydrophilicity yayo ithuthukiswa kakhulu.Ngemuva kokuguqulwa kwe-PEG, ayikwazi nje ukuhlangana eduze ne-albumin, ukumboza indawo ye-hydrolysis ye-enzyme ye-DPP-4, kodwa futhi yehlise ukuphuma kwezinso, yandise ingxenye yempilo yebhayoloji futhi ifinyelele umphumela womjikelezo omude.I-Somaglutide kaNovo Nordisk ilengise i-DPP-4′s Sigliptin, kanye nomsunguli we-GLP-1, i-exenatide esebenza isikhathi eside (kufanele yakhelwe ukuncintisana ikhanda nekhanda neqiniso lika-Lily. Ubuxhwanguxhwangu sebulokhu busemakethe isikhathi eside).Esivivinyweni, umthamo ophezulu we-Somicalbook wehle ngo-A1C1.6%, futhi ukwehla kwesisindo esiphezulu kwaba ngu-6 kg.I-Somaglutide isetshenziselwe ukuphenya ukusebenza kahle nokuphepha kwe-1.0mg Somaglutide uma kuqhathaniswa ne-2.0mg Exenatide kanye ngesonto ezigulini ze-813 ezinesifo sikashukela sohlobo lwe-2.Isikhathi sokuhlolwa sasingamaviki angama-56, futhi iziguli zathatha izidakamizwa ezilwa nesifo sikashukela eziyi-1-2 ngomlomo ngasikhathi sinye.NgoZibandlela wezi-2017, i-FDA yagunyaza ngokusemthethweni umuthi wamasonto onke we-GLP-1 we-hypoglycemic i-Somaglutide othuthukiswe yi-NovoNordisk ukuze udayiswe ngaphansi kwegama lokuhweba elithi Ozempic.Ngokwedatha yesilingo somtholampilo, i-Ozempic ingehlisa izinga le-HbA1c uma iqhathaniswa ne-placebo, i-Januvia yase-Merck, i-Bydureon yase-AstraZeneca ne-Lantus yase-Sanofi.Umuthi uphinde wakhombisa amandla okusiza iziguli ukuthi zehlise isisindo.