I-CAS: 38304-91-5 Minoxidil alostil lonolox

Isingeniso

I-Minoxidil, eyaziwa nangokuthi i-idine yokucindezela ende, i-Minoxidil, ifomula yamangqamuzana kanye nesisindo samangqamuzana esihlobene C9H15N5O = 209.25, i-crystalline powder emhlophe noma emhlophe, i-soluble kancane emanzini noma i-chloroform, i-soluble kancane ku-ethanol, i-soluble kancane ku-acetone, i-acetic acid.Ingakwazi ukusebenza ngokuqondile odongeni lwemithambo yegazi, ivule i-arterioles, inciphise ukumelana ne-peripheral, yehlise umfutho wegazi, futhi ikhulise izinga lokushaya kwenhliziyo nokuphuma kwenhliziyo.Kodwa-ke, umphumela wayo we-antihypertensive ubaluleke kakhulu futhi uhlala isikhathi eside kune-hydrazine.

Umphumela we-Pharmacological

I-Minoxidil ivula i-arterioles ngokuqondile, ngaleyo ndlela inciphise ukucindezeleka kwegazi, kodwa indlela eqondile ayaziwa.Lo mkhiqizo awuwandisi ama-venule.Ukwehliswa kokumelana nemithambo ye-peripheral kuholela ekushayeni kwenhliziyo okusheshayo kwe-reflex kanye nokwanda kokuphuma kwenhliziyo.Umsebenzi we-Renin ukhuphuka ngemuva kwe-hypotension, okuholela emanzini nokugcinwa kwe-sodium.Lo mkhiqizo awuphazamisi i-vascular motor Chemicalbook reflex, ngakho-ke i-orthostatic hypotension ayenzeki.I-Minoxidil iyisidakamizwa esivame ukusetshenziswa futhi esiphumelelayo ekwelapheni ukulahlekelwa izinwele, kodwa imiphumela yayo ye-pharmacological kanye namaseli okuhlosiwe akucaci kahle.Eminyakeni yamuva, ucwaningo luye lwabonisa ukuthi iMinoxidil ingase ikhuthaze ukukhula kwezinwele ngokusebenzisa izindlela ezilandelayo.

Isidakamizwa esiphuzwayo esisetshenziswa emtholampilo ukwehlisa umfutho wegazi

I-Minoxidil uhlobo lomuthi odluliselwa ngomlomo osetshenziselwa ukwehlisa umfutho wegazi emtholampilo, owaziwa nangokuthi i-Changbaridine, i-piperazine enediamine, i-hytenidine ne-Minlohemoidine.Kungokwe-ejenti yokuvula isiteshi se-potassium, engakwazi ukuphumula ngokuqondile imisipha ebushelelezi ye-vascular futhi inomphumela onamandla wokunciphisa umthambo omncane, ukunciphisa ukumelana ne-peripheral, ukunwetshwa kwe-vascular kanye nomfutho wegazi, kodwa akunawo umthelela emithanjeni yevolumu, ngakho-ke ingakhuthaza ukubuya kwe-venous.Ngesikhathi esifanayo, ukuphuma kwenhliziyo nokushaya kwenhliziyo kungandiswa ngenxa yokulawulwa kwe-reflex kanye nomphumela omuhle wokuvama, kodwa akubangeli i-postural hypotension.Emtholampilo isetshenziswa ekwelapheni umfutho wegazi ophakeme we-refractory kanye nomfutho wegazi ophakeme wezinso.Ingase futhi isetshenziselwe umfutho wegazi ophakeme ngokusabela kabi kwezinye izidakamizwa ze-antihypertensive, kodwa idinga ukuhlanganiswa nama-diuretics ukugwema ukugcinwa kwamanzi nokugcinwa kwe-sodium.Uma kuhlanganiswa nezidakamizwa ze-β-blocking, ukusebenza kwayo kungandiswa futhi kuncishiswe ukusabela okungekuhle.Omunye umphumela ohlangothini wokusetshenziswa kwesikhathi eside kwe-Minoxidil ne-Chemicalbook ukuthi izinwele zomzimba zingase zande kancane ngokuqhubeka nokusetshenziswa kwesidakamizwa, njengezinwele ezingalweni.Kodwa ngokuvamile ngaphakathi kwemingcele eyamukelekayo.Imiphumela emibi eyinhloko yokuphathwa komlomo ihlanganisa ukuzuza kwesisindo kanye ne-edema yemilenze ephansi ebangelwa ukugcinwa kwamanzi ne-sodium, ukushaya kwenhliziyo kanye ne-arrhythmia okubangelwa i-reflex sympathetic nerve excitation, kanye ne-hirsuism.Ukusabela okubi okuyinhloko kwamalungiselelo e-topical kwaba ukucasuka kwesikhumba, i-erythema, pruritus nokunye ukusabela kwe-dermatitis.Nakuba inani lokumunca ekulungiseleleni i-topical lincane kakhulu, alikwazi ukukhishwa ukuthi lingase libe nomthelela esimweni seziguli ezinomlando wesifo senhliziyo.Iziguli ezinesifo se-cerebrovascular, ukwehluleka kwenhliziyo okungabangelwa umfutho wegazi ophakeme, isifo senhliziyo, i-angina pectoris, i-myocardial infarction, i-pericardial effusion, ukungasebenzi kahle kwezinso nezinye izifo kufanele kusetshenziswe ngokucophelela, i-minoxidil allergy kanye ne-pheochromocytoma iziguli kufanele zivinjelwe.