Ukunikezwa kokukhiqiza Dihexa CAS 1401708-83-5
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Ukusetshenziswa:
I-DIHEXA (PNB-0408), i-oligoplase reagent, iyi-analog ye-IV ye-vascular tensionin IV enomsebenzi womlomo kanye nokungena kwe-blood-brain barrier.I-Dihexa enobungane kakhulu namandla ihlanganisa i-hepatocyte growth factor (HGF), inani le-ChemicalBookkd lingu-65PM, futhi ithuthukisa umsebenzi wayo kumamukeli we-C-MET.I-Dihexa ibonisa umsebenzi omuhle kakhulu we-anti -ejaculation futhi ithuthukise imisebenzi yengqondo kumamodeli ezilwane.I-Dihexa inamandla okutadisha isifo i-Alzheimer's.
I-Dihexa ibophezela ngokuhambisana okuphezulu ku-HGF futhi kokubili i-dihexa kanye nenhlanganisela yomzali wayo i-Norleucine 1-AngIV yenza i-c-Met phosphorylation phambi kokugxila kwe-subthreshold ye-HGF futhi ikhulise ukusabalalisa kwamaseli okuncike ku-HGF.Ngaphezu kwalokho, i-dihexa ne-Nle1-AngIV yenza i-hippocampal spinogenesis kanye ne-synaptogenesis efana ne-HGF ngokwayo.I-Dihexa ivimbela ngempumelelo i-HGF dimerization ku-1 μM. Ngenkathi i-dihexa ku-1 nM kanye no-10 pM iyodwa ingayisebenzisi i-c-Met, ikhulisa ngokuphawulekayo umthamo we-HGF ku-1.25 kanye no-2.5 ng/mL ukuze iqalise i-c-Met.
I-Dihexa ine-half-life ejikelezayo ende.I-Dihexa ibonisa umsebenzi wokuqonda.I-Dihexa ihlehlisa ukushoda kokufunda kwendawo okuncike ku-scopolamine.Ithuthukisa ukufunda kwendawo kumagundane asebekhulile.I-Dihexa yenza i-spinogenesis kuma-neuron e-hippocampal akhulisiwe.
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