Ukunikezwa Kokukhiqiza 99% I-Purity White Powder Antitumor Polypeptide Pharma Ibanga Lokucwaninga Ngomdlavuza I-MELITTIN CAS 20449-79-0

I-MELITTIN CAS 20449-79-0 Ukusetshenziswa:

I-Melitin iyisithako esiyinhloko esisebenzayo sobuthi bezinyosi.I-Beevenom iwuhlobo lwesihlungu esisobala nephunga elimnandi elikhishwa izindlala zesisebenzi sezinyosi kanye nezinsimbi ezisetshenziswayo.Uma sephulwe, siyakhishwa odongeni.Phakathi kwezingxenye eziningi ze-bee venom, i-melittin inokuqukethwe okuphezulu kakhulu, okulinganiselwa ku-50% wesisindo esomile se-bee venom, futhi inomsebenzi ophezulu wezinto eziphilayo.I-Melittin iyi-peptide eqondile eyakhiwe ngama-amino acid angama-26, enesisindo samangqamuzana esingama-2849. I-Melittin inomsebenzi ophezulu wezinto eziphilayo.Ucwaningo lwesimanje lwe-pharmacological lubonise ukuthi ine-anti-inflammatory, analgesic, inhibiting platelet aggregation, anti-AIDS kanye neminye imiphumela eminingi.I-Melittin ingakhiqiza umphumela oqinile wokubulala kumaseli ahlukahlukene wesimila ngokusebenzisa izindlela ezihlukene, futhi iyisidakamizwa semvelo esithembisa kakhulu esilwa nesimila.

I-Melittin ingavimbela ukukhula nokukhiqizwa kabusha kwezinhlobo ezingaphezu kwama-20 zamabhaktheriya e-Gram-positive kanye nama-negative, futhi ingathuthukisa ukusebenza kahle kwe-antibacterial ye-sulfonamides nama-penicillin.I-Melittin ibhubhisa ulwelwesi lwamaseli ebhaktheriya ngokubopha kulwelwesi ukuze kufezwe inhloso ye-bacteriolysis.Kokubili i-melittin kanye nokuphuma kwayo okuyisithupha kungashintsha ukusebenza kwama-T lymphocyte atheleleke nge-HIV, kuvimbele ukuphindaphindeka kwe-HIV, futhi kunciphise ukusuleleka kwegciwane.

1. Umthelela wokubulala oqondile Ukuhlolwa kwe-In vitro kuqinisekisile ukuthi i-melittin inomphumela osobala wokubulala emigqeni yamaseli e-tumor ahlukahlukene njenge-osteosarcoma, umdlavuza we-ovarian, ne-glioma, futhi umphumela wokubulala uhlotshaniswa kahle nomthamo.I-Melittin ingabulala amaseli wesimila futhi ivimbele ukukhula kwamangqamuzana e-tumor, futhi ayinawo umthelela osobala ekukhuleni kwamaseli ajwayelekile.I-Melittin ingafaka kulwelwesi lwamaseli we-K562, yenze izimbotshana, ikhuthaze ukungena kwe-Ca2 +, ikhulise ukugcwala kwe-Ca2 + kumaseli, ibangele i-cell lysis, futhi ibulale ngokuqondile amaseli e-K562.Ngokuvamile kunenkolelo yokuthi i-melittin incibilikisa ulwelwesi lwamangqamuzana lwe-mitochondrial, ivimbele ukusebenza okuvamile kokuphefumula kwamangqamuzana esimila, ibhubhise ikhono lawo lokuphefumula le-aerobic, ivimbele ukukhula kwezicubu zesimila, futhi ibulale ngokuqondile amaseli wesimila.
2. Umphumela we-Immunomodulatory Ukungavikeleki kweselula kuyisici esibalulekile sokuvikela umzimba ngokumelene namathumba kanye nezifo ezibangelwa amagciwane.Isimo sokusebenza kwamasosha omzimba omzimba sidlala indima ebalulekile ekuveleni nasekuthuthukisweni kwezimila.Ukuthuthukisa ukusebenza kwamasosha omzimba kungadlala umphumela othile wokulwa nesimila.
3. Ukungeniswa kwe-tumor cell apoptosis I-Apoptosis, eyaziwa nangokuthi i-programmed cell death, inqubo yebhayoloji yeseli esebenzayo elawulwa izinhlobonhlobo zezakhi zofuzo.Ngakho-ke, i-apoptosis iyinqubo esebenzayo, ebandakanya ukwenziwa kusebenze, ukuvezwa kanye nokulawulwa kochungechunge lwezakhi zofuzo.Ucwaningo lwesimanje lubonise ukuthi izidakamizwa eziningi ze-chemotherapeutic zingafinyelela izinhloso zokwelapha ngokufaka i-apoptosis kumaseli omdlavuza.Ukuthi ukunxenxa i-apoptosis sekungenye yezindlela zokuhlola izidakamizwa ezilwa nomdlavuza.

I-Melittin ingavimbela umsebenzi we-sPLA2 emithonjeni ehlukahlukene, futhi izinga lokuvinjelwa komsebenzi we-sPLA2 ku-synovial fluid yeziguli ze-RA lingafinyelela ku-96%.Ngakho-ke, ukusetshenziswa kwe-melittin kunganciphisa ukuthuthukiswa kwe-RA.

I-sub-dose ye-melittin inganciphisa kakhulu izinga le-lysis lokuhambisana namaseli.Le nqubo yokuvikela ingase ihlotshaniswe ne-melittin ekhuthaza ukungena kwe-Ca2 +, ukuvuselela uhlelo lwe-intracellular transduction system kanye nokuvikela amaprotheni synthesis.Kuphakanyiswa ukuthi ukusetshenziswa kwenani elifanele le-melittin kunenani elithile lomtholampilo ekwelapheni i-RA nge-Chemicalbook.Eminyakeni yamuva nje, ucwaningo luye lwabonisa ukuthi ukugxila okuhlukile kwe-melittin kungathinta ukusebenza kwamaseli ngokusebenzisa iziteshi ezihlukene futhi kube nemiphumela ehlukahlukene yezinto eziphilayo.Ukusetshenziswa okufanele kwe-melittin kuzohlinzeka ngokwelashwa okusha kwezinye izifo.