HU-210 INOMBOLO YECAS: 112830-95-2

I-HU-210 iyi-(--) enantiomer ye-11-OH-D 8-THC-DMH, cishe cishe yonke imisebenzi yama-cannabinoids, kuyilapho (+) enantiomer, ebizwa ngokuthi i-HU-211, ayisebenzi njenge-cannabinoid, kodwa Isebenza njenge-cannabinoid njengomphikisi we-NMDA onemiphumela ye-neuroprotective.

I-HU-210 ingase ikhuthaze ukwanda, kodwa hhayi ukuhlukaniswa, kwamangqamuzana e-embryonic hippocampal neural stem namaseli omzali ngokwenza kusebenze isamukeli se-CB 1, iphrotheni ye-G i/o, nokusayina kwe-ERK ngokulandelanayo.Lokhu kukhula kwezinzwa kwanda futhi kukhombisa isidingo semiphumela elwa nokukhathazeka kanye ne-anti-depressive.

Kanye namanye ama-cannabinoids okwenziwa, afana ne-WIN 55,212-2 kanye ne-JWH-133, i-HU-210 ivikela ukuvuvukala okubangelwa isifo se-Alzheimer's-associated beta amyloid, ngaphezu kokuvimbela ukukhubazeka kwengqondo nokulahlekelwa izimpawu ze-neuronal.Lo mphumela wokulwa nokuvuvukala ubangelwa ukusebenza kwama-cannabinoid receptors, okuvimbela ukusebenza kwamaseli e-microglia avuthayo.Ngaphezu kwalokho, ama-cannabinoids aqede ngokuphelele i-neurotoxicity ehambisana nokusebenza kweseli le-microglial kumamodeli wamagundane.

I-HU-210 iyisidambisa-zinhlungu esinamandla esinemiphumela eminingi efana ne-THC yemvelo.

I-LD50 yomlomo ye-HU-210 ingu-5,000mg/kg kumagundane kanye no-14,200mg/kg konogwaja.I-LDLO (umthamo ophansi obulalayo) we-HU-210 kubantu ngu-143mg/kg.I-LD50 ye-caffeine ilinganiselwa ku-150-200 mg/kg.I-Delta-8-THC LD50 ayikaqinisekiswa.Ocwaningweni lwango-1973, izinkawu nezinja ezinikezwe i-9,000 mg/kg ye-Delta-8-THC zazingabulali.