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I-High Purity Pharma API CAS14769-73-4 Hydrochloride Levamisole Base

incazelo emfushane:


  • Igama elijwayelekile:Levamisole
  • Inombolo ye-CAS:14769-73-4
  • MF:I-C11H12N2S
  • MW:204.29
  • I-EINECS:238-836-5
  • Iphoyinti lokuncibilika:60-61.5°
  • i-alpha:I-D25 -85.1° (c = 10 ku-chloroform)
  • Indawo yokubilisa:344.4±45.0 °C(Kubikezelwe)
  • ukuminyana :1.32±0.1 g/cm3(Kubikezelwe)
  • Izinga lokushisa lokulondoloza:Ivalwe endaweni eyomile, engu-2-8°C
  • pka:10.00±0.40(Okubikezelwe)
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    Ulwazi Oluyisisekelo

    I-CAS14769-73-4 Hydrochloride Levamisole Base

    Incazelo

    I-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole enokumiswa kwe-S.Isetshenziswa (ngokuvamile njengosawoti we-monohydrochloride) ukwelapha izifo zezikelemu ezingulubeni, ezimvini nasezinkomeni futhi ngaphambili yayisetshenziswa ku-huma njenge-adjuvant ku-chemotherapy ekwelapheni imidlavuza ehlukahlukene.Ibuye isetshenziswe kabanzi njengephinga ku-coccaine.

    Izinkomba

    I-Levamisole (Ergamisol) iyisidakamizwa esilwa ne-antiparasite esitholwe ukuthuthukisa ukusebenza kwe-T-cell kanye nokuvikeleka kwamaselula.Umuthi uthuthukisa ukusinda kweziguli ezinomdlavuza we-colorectal okhishiwe lapho uhlanganiswa ne-5-fluorouracil;indlela yalokhu kusebenzisana akwaziwa.I-Levamisole ayinawo umsebenzi we-antitumor ngokumelene nomdlavuza osunguliwe noma we-metastatic futhi ayikatholakali iwusizo ekwelashweni kwe-adjuvant komdlavuza ngaphandle komdlavuza we-colorectal.

    Imiphumela emibi emikhulu ye-levamisole isicanucanu kanye ne-anorexia.Ukuqubuka kwesikhumba, ukulunywa, izimpawu ezinjengomkhuhlane, nemfiva nakho kuye kwabonakala.

    Izinkomba

    I-Levamisole (Ergamisol) ekuqaleni yasungulwa njengesidakamizwa se-antihelminthic.Ithuthukisa imiphumela evuselelayo yama-antigen, ama-mitogen, ama-lymphokines, nezici ze-chemotactic kuma-lymphocytes, ama-granulocytes, nama-macrophage.Kuye kwaboniswa ukwandisa ukungatheleleki kwe-T cell-mediated.

    I-Levamisole isetshenziswe ngempumelelo ekwelapheni izifo ezingelapheki.Iphinde yagunyazwa ukuthi isetshenziswe ngokuhambisana ne-fluorouracil ekwelapheni umdlavuza we-colorectal.

    I-CAS 94-15-5
    Levamisole
    Levamisole

    Ukusetshenziswa

    Isebenzisa Isilungisi sempendulo yebhayoloji.

    Isebenzisa   I-Levamisole isetshenziselwa izimo ze-immunodeficient yokuqala neyesibili, izifo ezizimele, izifo ezingelapheki neziphindaphindayo, i-adenocarcinoma yamathumbu amakhulu, i-helmintosis, ne-rheumatoid arthritis.Izimpawu ezifanayo zalesi sidakamizwa yi-decaris, i-tetramizole, nezinye.

    I-Levimasole nayo iyisidakamizwa esikhethwa yi-ascardiasis.Uphenyo oluningi lubonisa ukuthi umthamo owodwa we-levamisole welapha kusukela ku-90 kuya ku-100% weziguli ezine-ascardiasis, ikakhulukazi lezo ezine-A. duodenale.Ayisebenzi kahle ngokumelene ne-ancylostomiasis kanye ne-strongyloidiasis.Nokho, ayisebenzi ngokumelene ne-N. americanus.Kubonakala sengathi inomphumela ovuselela i-gangliostimulating ezicutshini ze-parasite kuzo zombili izifunda ze-parasympathetic nezinozwela.Ngaphezu kwalokho, kucatshangwa ukuthi lesi sidakamizwa sinomphumela we-immunomodulatory emzimbeni ophethe.Igama elifanayo lalesi sidakamizwa yi-decaris, i-solacil, i-ergamisol, i-tramisol, i-immunol, nabanye.

    Ukusetshenziswa Kwezokwelapha

    I-Ascariasis Ukutheleleka kweHookworm

    I-Levamisole isetshenziswe ku-rheumatoid arthritis kanye nezinye izimo okuthiwa zisabela emsebenzini wayo wokuzivikela komzimba.

    Umsebenzi Wokwelapha

    I-Antiinflammatory

    Umsebenzi we-antimicrobial

    Umsebenzi wayo oyinhloko uphikisana ne-Asc.ama-lumbricoides kanye nezikelemu.Izikelemu ziyakhubazeka bese ziphumela endle emahoreni ambalwa.

    Izicelo Zemithi

    I-l-isomer ye-tetramisole, etholakala njenge-monohydrochloride.I-d-isomer ayinawo umsebenzi we-anthelmintic.Incibilika kakhulu emanzini futhi izinzile esimweni esomile.

    Indlela yokwenza

    I-Levamisole inomsebenzi we-immunomodulating.Kukholakala ukuthi ilawula izinqubo zamangqamuzana amasosha omzimba, futhi indlela yesenzo sayo ingase ihlotshaniswe nokusebenza kanye nokukhula okukhulayo kwe-T-lymphocyte, izinombolo ezikhulayo zama-monocyte kanye nokusebenza kwama-macrophages, kanye nomsebenzi owandayo kanye ne-hemotaxis ye-neutrophylic. ama-granulocyte.I-Levamisole futhi ibonisa isenzo se-anthelminnt.Iphinde ikhulise ukumelana nomzimba jikelele futhi ibuyisele umsebenzi oshintshile we-T-lymphocyte kanye ne-phagocyte.Ingakwazi futhi ukufeza umsebenzi we-immunomodulatory ngokuqinisa ukusabela okubuthakathaka kokuvikeleka kwamangqamuzana, ukwenza buthaka ukusabela okuqinile, futhi kungabi nomthelela ekuphenduleni okuvamile.


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