I-High Purity Pharma API CAS14769-73-4 Hydrochloride Levamisole Base
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Ulwazi Oluyisisekelo
Incazelo
I-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole enokumiswa kwe-S.Isetshenziswa (ngokuvamile njengosawoti we-monohydrochloride) ukwelapha izifo zezikelemu ezingulubeni, ezimvini nasezinkomeni futhi ngaphambili yayisetshenziswa ku-huma njenge-adjuvant ku-chemotherapy ekwelapheni imidlavuza ehlukahlukene.Ibuye isetshenziswe kabanzi njengephinga ku-coccaine.
Izinkomba
I-Levamisole (Ergamisol) iyisidakamizwa esilwa ne-antiparasite esitholwe ukuthuthukisa ukusebenza kwe-T-cell kanye nokuvikeleka kwamaselula.Umuthi uthuthukisa ukusinda kweziguli ezinomdlavuza we-colorectal okhishiwe lapho uhlanganiswa ne-5-fluorouracil;indlela yalokhu kusebenzisana akwaziwa.I-Levamisole ayinawo umsebenzi we-antitumor ngokumelene nomdlavuza osunguliwe noma we-metastatic futhi ayikatholakali iwusizo ekwelashweni kwe-adjuvant komdlavuza ngaphandle komdlavuza we-colorectal.
Imiphumela emibi emikhulu ye-levamisole isicanucanu kanye ne-anorexia.Ukuqubuka kwesikhumba, ukulunywa, izimpawu ezinjengomkhuhlane, nemfiva nakho kuye kwabonakala.
Izinkomba
I-Levamisole (Ergamisol) ekuqaleni yasungulwa njengesidakamizwa se-antihelminthic.Ithuthukisa imiphumela evuselelayo yama-antigen, ama-mitogen, ama-lymphokines, nezici ze-chemotactic kuma-lymphocytes, ama-granulocytes, nama-macrophage.Kuye kwaboniswa ukwandisa ukungatheleleki kwe-T cell-mediated.
I-Levamisole isetshenziswe ngempumelelo ekwelapheni izifo ezingelapheki.Iphinde yagunyazwa ukuthi isetshenziswe ngokuhambisana ne-fluorouracil ekwelapheni umdlavuza we-colorectal.
Ukusetshenziswa
Isebenzisa Isilungisi sempendulo yebhayoloji.
Isebenzisa I-Levamisole isetshenziselwa izimo ze-immunodeficient yokuqala neyesibili, izifo ezizimele, izifo ezingelapheki neziphindaphindayo, i-adenocarcinoma yamathumbu amakhulu, i-helmintosis, ne-rheumatoid arthritis.Izimpawu ezifanayo zalesi sidakamizwa yi-decaris, i-tetramizole, nezinye.
I-Levimasole nayo iyisidakamizwa esikhethwa yi-ascardiasis.Uphenyo oluningi lubonisa ukuthi umthamo owodwa we-levamisole welapha kusukela ku-90 kuya ku-100% weziguli ezine-ascardiasis, ikakhulukazi lezo ezine-A. duodenale.Ayisebenzi kahle ngokumelene ne-ancylostomiasis kanye ne-strongyloidiasis.Nokho, ayisebenzi ngokumelene ne-N. americanus.Kubonakala sengathi inomphumela ovuselela i-gangliostimulating ezicutshini ze-parasite kuzo zombili izifunda ze-parasympathetic nezinozwela.Ngaphezu kwalokho, kucatshangwa ukuthi lesi sidakamizwa sinomphumela we-immunomodulatory emzimbeni ophethe.Igama elifanayo lalesi sidakamizwa yi-decaris, i-solacil, i-ergamisol, i-tramisol, i-immunol, nabanye.
Ukusetshenziswa Kwezokwelapha
I-Ascariasis Ukutheleleka kweHookworm
I-Levamisole isetshenziswe ku-rheumatoid arthritis kanye nezinye izimo okuthiwa zisabela emsebenzini wayo wokuzivikela komzimba.
Umsebenzi Wokwelapha
I-Antiinflammatory
Umsebenzi we-antimicrobial
Umsebenzi wayo oyinhloko uphikisana ne-Asc.ama-lumbricoides kanye nezikelemu.Izikelemu ziyakhubazeka bese ziphumela endle emahoreni ambalwa.
Izicelo Zemithi
I-l-isomer ye-tetramisole, etholakala njenge-monohydrochloride.I-d-isomer ayinawo umsebenzi we-anthelmintic.Incibilika kakhulu emanzini futhi izinzile esimweni esomile.
Indlela yokwenza
I-Levamisole inomsebenzi we-immunomodulating.Kukholakala ukuthi ilawula izinqubo zamangqamuzana amasosha omzimba, futhi indlela yesenzo sayo ingase ihlotshaniswe nokusebenza kanye nokukhula okukhulayo kwe-T-lymphocyte, izinombolo ezikhulayo zama-monocyte kanye nokusebenza kwama-macrophages, kanye nomsebenzi owandayo kanye ne-hemotaxis ye-neutrophylic. ama-granulocyte.I-Levamisole futhi ibonisa isenzo se-anthelminnt.Iphinde ikhulise ukumelana nomzimba jikelele futhi ibuyisele umsebenzi oshintshile we-T-lymphocyte kanye ne-phagocyte.Ingakwazi futhi ukufeza umsebenzi we-immunomodulatory ngokuqinisa ukusabela okubuthakathaka kokuvikeleka kwamangqamuzana, ukwenza buthaka ukusabela okuqinile, futhi kungabi nomthelela ekuphenduleni okuvamile.