GW-0742 SARMs Powder |I-GW610742 CAS 317318-84-6

incazelo emfushane:

GW-0742
Igama Lekhemikhali:[4--[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid
Omqondofana:GW610742 noma GW0742
Inombolo ye-CAS :317318-84-6
I-Chemical Formula:I-C21H17F4NO3S2
Isisindo se-Molecular:471.5
Ubumsulwa:Hhayi ngaphansi kuka-99.0% (HPLC)
Ukubukeka:I-crystalline eqinile
I-GW0742 Melting Point:134.5- 135.5 °C
Isitoreji:Gcina ekamelweni lokushisa, livalwe ngokuqinile, kude nokushisa, ukukhanya nomswakama.
Isicelo:I-SARM entsha efana ne-GW501516

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

Ukusetshenziswa

Ngokukhuluphala ngokweqile, isifo sikashukela, i-dyslipidemia nesifo senhliziyo Umuthi wokuhlola owawuhloselwe ukulawula i-lipids nokwandisa izinga le-HDL, noma i-cholesterol enhle, egazini.I-cell-permeable, inhlanganisela ye-thiazolyl esebenza njengenamandla, ukuhlobana okuphezulu, i-agonist ye-PPARδ.Ibonisa ukukhetha kwe-PPARδ uma kuqhathaniswa ne-PPARα ne-PPARγ.Ayiphumi kunoma yimuphi umsebenzi ngokumelene namanye ama-nuclear noma ama-non-nuclear receptors.Kubikwa ukuthi kwenyusa i-cholesterol efflux kanye nenkulumo ye-ABAC1 kuma-macrophages, ama-fibroblasts, namaseli amathumbu.

I-Cardarine isetshenziswa abasubathi abaqhudelana emidlalweni eminingi ehlukene.Isibonelo, abasubathi bokubekezela bangase bakhulise ukukhuthazela kokuzivocavoca ngokupakisha le PPAR nesidakamizwa se-analog se-AMP i-AICAR, noma baqhube i-cardarine solo.Ngenxa yalokho, bazoba nekhono elikhulu lokufinyelela ama-RPM aphezulu phakathi nokugijima kwabo ngaphandle kokushaya umkhawulo wokushaya kwenhliziyo.Lokhu kuzovumela umgijimi/umgibeli wamabhayisikili/umbhukudi ukuthi akhohlise izinga eliphezulu lokushaya kwenhliziyo futhi ahambe isikhathi eside ngaphandle kokushaywa umoya, okwenza lesi sitaki sibe isikhali esimangalisayo esingasisebenzisa emidlalweni yokukhuthazela.Eqinisweni, ngokuhlangenwe nakho kwami ngingasho ukuthi i-cardarine ingangqongqoza ngaphezu kwemizuzwana engu-30-45 ngesikhathi se-5K uma isetshenziselwa ukuholela emncintiswaneni.

Incazelo

AMAGAMA AYINHLOKO:Ukulahlekelwa amafutha, thuthukisa ukukhuthazela, akukho mphumela ongemuhle, umakhi womzimba,ukwelapha ukukhuluphala kanye nokusiza ukugcina isisindo esithambile, kwandisa izicubu zomzimba.

I-Cardarine (GW-501516) ihlelwe esigabeni se-SARMS, noma kunjalo ngesakhiwo nencazelo, i-modulator ye-PPAR.Njengemoduli ye-PPAR, yenza kusebenze i-protein kinase ecushwe yi-AMP futhi ikhuthaze ukumuncwa kwe-glucose kuzicubu zemisipha yamathambo.I-GW-501516 inamakhono okubuyisela emuva izinkinga ze-metabolism ngokuvuselela i-fatty acid oxidation.Kubhekwa njengokwelashwa okunamandla kokukhuluphala nezinye izimo ezihlobene.

I-GW501516 igama lomuthi we-Glaxo Wellcome (i-GW imele inkampani futhi inombolo yomkhiqizo).Yaziwa nangokuthi GW-501,516, GW1516, GSK-516).Kuyi-PPARδ receptor agonist engazange ithathwe ngaphezu kokuhlolwa komtholampilo.Ngaleyo ndlela ivaliwe kwezemidlalo.Ilingana nenani lezindawo ohlwini, okuhlanganisa ngokuqondile “njenge-peroxisome Proliferator Activated Receptor δ (PPARδ) agonists (isb. GW501516)”.Kodwa izophinde ibe ngaphansi kwesigaba esisha se-WADA sokubamba zonke “izinto ezingagunyaziwe” okuhloswe ngazo ukumisa noma yisiphi isidakamizwa esingagunyaziwe esisetshenziswa abasubathi.

I-GW501516 (eyaziwa nangokuthi i-GW-501,516, GW1516, GSK-516) iyi-PPAR& receptor agonist eyasungulwa ngokubambisana phakathi kwe-Ligand Pharmaceuticals kanye ne-GlaxoSmithKline ngawo-1990, yafakwa ekuthuthukisweni komtholampilo njengomuntu ozokhethwa ezidakamizwa zezifo ze-metabolic kanye nenhliziyo. , futhi yashiywa ngo-2007 ngoba ukuhlolwa kwezilwane kwabonisa ukuthi umuthi wabangela umdlavuza ukuba uthuthuke ngokushesha ezithweni eziningana.

Ngo-2007 ucwaningo lwanyatheliswa olubonisa ukuthi imithamo ephezulu ye-GW501516 enikezwe amagundane yathuthukisa kakhulu ukusebenza kwawo ngokomzimba;umsebenzi waxoxwa kabanzi emithonjeni yezindaba edumile, futhi kwaholela emakethe emnyama yomuntu ozongenela izidakamizwa kanye nokuhlukunyezwa kwawo ngabasubathi njenge-ejenti ye-doping.

Izinhlelo zokusebenza

I-GW501516 ingasetshenziswa abasubathi njengesidakamizwa esithuthukisa ukusebenza kwe-ergogenic esasingalawulwa yimithethonqubo noma sitholwe ngokuhlolwa okujwayelekile.Omunye wabacwaningi abayinhloko ocwaningweni lokukhuthazela okuthuthukisiwe ngenxa yalokho wenza ukuhlolwa komchamo ukuze athole umuthi, futhi wawenza watholakala eKomidini Lamazwe Ngamazwe Lama-Olympic.

I-GW ivuselela ukumuncwa kwe-glucose kanye nezicubu zemisipha yamathambo.Ishisa amafutha ngokuvuselela i-fatty acid oxidation.Kuphakanyiswa njengendlela yokwelapha ukukhuluphala ngokweqile ngenxa yekhono layo lokuncibilikisa amafutha ngokushesha.Futhi, i-Cardarine kuthiwa yandisa i-HDL ngesilinganiso se-79% (i-cholesterol enhle) futhi yehlise i-LDL (i-cholesterol embi) ekuhlolweni kwamanje kweSigaba II.I-GW 501516 iyi-agonist ye-PPARδ.Lokhu kusiza ukukhulisa amazinga akho e-HDL kusukela ekukhulumeni okuthuthukisiwe kwesithuthi se-cholesterol i-ABCA1.