I-Glucagon CAS: 16941-32-5 IGlucagon(1-29) I-HCl Yomuntu I-GLUCAGON 1-37

I-Glucagon, eyaziwa nangokuthi i-hyperglycemin ne-glucagon, iyi-hormone ye-polypeptide yeketango eliqondile ekhishwa amaseli e-α e-pancreatic islet, equkethe ama-amino acid angama-29.Ifomula yayo yamangqamuzana nesisindo samangqamuzana esihlobene yi-C153H225N43O49S=3482.8.Le hormone yenziwe ezweni lami.Impushana ecwebezelayo emhlophe emazingeni okushisa ekamelo, ayinaphunga, ayinambitheki.Ayincibiliki emanzini nasezincibilikisini eziningi eziphilayo, inyibilika ku-asidi exubileyo futhi ihlanza i-lye.Amalungiselelo amaningi enziwa nge-hydrochloride yayo, encibilika emanzini.Manje sekuyaziwa ukuthi i-glucagon kumele igcine ubuqotho bayo be-molecule ukuze yenze umsebenzi wayo wokuphila.Isakhiwo se-hyperglycemic singase singaguquki kubantu nezilwane ezincelisayo (onogwaja, izinkomo, izingulube, amagundane, njll.), kodwa zihluke kancane ezinyoni.Kuyi-hormone ebalulekile yokugcina ushukela wegazi ojwayelekile.Umsebenzi wayo oyinhloko ukwenza kusebenze i-phosphorylase ku-myocardium, ukukhuthaza ukubola kwe-glycogen futhi kube nemiphumela efana ne-catecholamin.Ngakho-ke, kunomphumela oqinile wenhliziyo enhliziyweni, okwandisa izinga lokushaya kwenhliziyo, ukufinyela kwe-myocardial kanye nokugeleza kwegazi le-coronary.Ukuthuthukiswa kwe-Cardioenhancement akuhambisane nokukhuphuka kwe-cardiac excitability, kodwa kwandisa i-calcium ions ku-cardiomyocytes futhi kungenza i-adenosine cyclase isebenze kulwelwesi lweseli yesibindi ku-Chemicalbook, ikhuthaze ukuhlanganiswa kwe-cyclic adenosine phosphate kumaseli.IGlucagon kubikwa ukuthi iyasebenza kwezinye izimo zokuhluleka kwenhliziyo.Ngaphezu kwalokho, amazinga e-plasma nawo anda aba ngamazinga ahlukahlukene esifo sikashukela, isifo sesibindi, isifo sezinso, isimila seglucagon nokucindezeleka.I-Glucagon inemisebenzi emine ye-physiological yokukhuthaza i-glycogenolysis yesibindi, i-glycogenogenesis yesibindi, i-lipolysis kanye nokwakheka komzimba we-ketone.Ingakhuthaza ukutholwa kwama-amino acid kumaseli esibindi, isheshise inqubo yokususa ama-amino acid esibindini, inciphise ukugcwala kwama-amino acid ku-plasma, inciphise ukwakheka kwamaprotheni futhi ikhuthaze isibindi se-glycogenogenesis.Ngaphezu kwalokho, kungase futhi kusebenze umthamo we-lipase wamangqamuzana okugcina i-lipid esibindi, kwandise ukukhululwa kwamafutha acid amahhala, kusheshise inqubo ye-lipoic acid oxidation yamaseli esibindi, futhi kwandise ukukhiqizwa kwesibindi i-glyccoconeogenesis nemizimba ye-ketone.Ngasikhathi sinye, i-glucagon ingavimbela ukungezwani kanye ne-peristalsis yesisu, amathumbu amancane kanye nekholoni, inciphise ukungezwani kwe-gallbladder, ivimbele i-pancreatic exocrine, futhi ivimbele ukumuncwa kwamanzi nosawoti nge-mucosa yamathumbu.Imithamo emikhulu yeglucagon nayo ingakhuphula ukugxila kwe-cAMP kumaseli e-myocardial, ikhuphule izinga lokushaya kwenhliziyo futhi ithuthukise ukufinyela kwe-myocardial.