Umkhiqizo wamakhemikhali i-Bromazolam CAS 71368-80-4
Ulwazi Oluyisisekelo
Ifomula yemolekyuli: C17H13BrN4
- Indawo encibilikayo: 272.0-275 ℃
- Indawo yokubilisa: 519.8±60.0 °C(Kubikezelwe)
- ukuminyana: 1.54±0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37±0.40(Kubikezelwe)
- I-Molecular Formula: C17H13BrN4
- Isisindo se-Molecular: 353.21600
- IMisa ngqo: 352.03200
- I-PSA: 43.07000
- Idatha ye-3.12480
Ukusetshenziswa
I-Bromazolam ihlukaniswa njengenoveli i-benzodiazepine eyaqala ukuhlanganiswa ngo-1976, kodwa ayizange idayiswe.Ngemuva kwalokho ithengiswe njengomuthi womklami, okokuqala wakhonjwa ngokucacile yi-EMCDDA e-Sweden ngo-2016. Yi-bromo esikhundleni se-chloro analogue ye-alprazolam, futhi inemiphumela efanayo yokudambisa kanye ne-anxiolytic.I-Bromazolam ngokwesakhiwo ifana ne-benzodiazepines yendabuko, okuhlanganisa i-alprazolam (ishintsha i-chlorine nge-bromine) ne-bromazepam (ukwengezwa kweringi ye-triazole).I-Alprazolam ne-bromazepam yizinto zeSheduli IV e-United States;i-bromazolam ayihleliwe ngokusobala.
I-8-Bromo-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine isetshenziselwa ukutadisha umsebenzi wokulwa nokukhathazeka, i-antidepressant kanye ne-psychotropics yesistimu yezinzwa ephakathi.
Indlela Yokulungiselela
Belashwe nge-PHLS9 (2 mg protein /mL), 25 μg/mL Alamethicin (UGT reaction ingxube B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, kanye no-0.6 mM ku-37° C NADP +, 0.9 U/mL isocitrate dehydrogenase, 100 U/mL superoxide dismutase kanye no-0.1 mM acetyl-CoA.Bese, 2.5 mM UDP-glucuronic acid (UGT reaction ingxube isisombululo A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, kanye 50 μM clobromazolam noma Bromazolam.
Izimo zokusabela:50 μM Bromazolam imizuzu engu-360 ku-37°C
Izicelo:I-Bromazolam metabolites yayikhonaikhonjiweku-pHLS9 incubation.