I-Chemical Material Izidakamizwa ezisizayo Izidakamizwa ezisizayo CAS 59-46-1 PROCAINE
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Ulwazi Oluyisisekelo
Incazelo
I-Procaine iyisibulala-zinzwa sasendaweni esinomsebenzi we-para-amino.Ukuzwela kuthinta ikakhulukazi umsebenzi wezokwelapha, wamazinyo nowezilwane.
Chemical Properties
Usawoti we-hydrochloride we-2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 noma i-N2C6H4COOCH2CH2NH(C2H5)2HCl) ngokuvamile ubizwa ngokuthi i-procaine.Nakuba i-PABA ester ingancibiliki emanzini, usawoti we-hydrochloride uncibilika kakhulu emanzini.
Isebenzisa
I-1.I-Procaine (i-Novocain) isetshenziselwa ikakhulukazi izinqubo zamazinyo noma zezokwelapha ezidinga i-anesthesia yokungena, i-peripheral block, noma i-spinal block.
I-2.inhibitor yesiteshi se-sodium
3. I-Procaine iyisivimbeli sesiteshi se-sodium kanye ne-inhibitor yezinqubo ezihlukahlukene.
Ukusetshenziswa
Ukusetshenziswa KwezokwelaphaI-procaine igaywa ngokushesha ku-plasma ngama-cholinesterase nasesibindini nge-ester hydrolysis nge-pseudocholinesterase.I-in vitroelimination half-life cishe imizuzwana engama-60.Noma yisiphi isimo esinciphisa ukugxila kwe-cholinesterase singase sikhulise ukuchayeka ku-procaine kanye nobuthi obungaba khona.Ukuncipha komsebenzi we-enzyme kungatholakala ngokuntuleka kofuzo, isifo sesibindi, ukonakala, ukungondleki, ukwehluleka kwezinso, ukusha, i-thirdtrimester yokukhulelwa, kanye nokulandela ukuhlinzwa kwe-cardiopulmonary bypasssurgeon.I-Ester hydrolysis ikhiqiza i-PABA, i-compounds ebhekele ukungezwani komzimba okuvamile kuma-anesthetics e-theester.I-Procaine ayisetshenziswa ngokwezihloko ngenxa yokungakwazi ukudlula kulwelwesi lwe-lipid futhi ithola ukusetshenziswa njenge-aninfiltration ejenti yolwelwesi lwesikhumba noma lwamafinyila, izinqubo ezifushane.I-Procaine iphinde isetshenziselwe ukuvimba izinzwa ezithintekayo futhi njenge-ejenti ye-epidural ukuze kuhlonzwe izimpawu zobuhlungu.