INOMBOLO YE-CAS;1631074-54-8 SGT-78 CUMYL-4CN-BINACA CUMYL-CYBINACA
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Ukusetshenziswa
I-CUMYL-4CN-BINACA (ephinde yaziwe nge-CUMYL-CYBINACA noma i-SGT-78) iyi-cannabinoid yokwenziwa esekelwe ku-indazol-3-formamide emaketheke ku-inthanethi njengomuthi okhethekile.I-agonist enamandla yama-cannabinoid receptors CB 1 kanye ne-CB 2, ne-in vitro EC 50 amanani we-0.58 nM kanye ne-6.12 nM, ngokulandelana.Kumagundane, i-CUMYL-4CN-BINACA ikhiqiza i-hypothermia futhi idala ukudlikizeka ngesenzo se-CB 1 receptor, futhi imibiko ye-anecdotal iphakamisa umthamo osebenzayo ongaba ngu-0.1 mg kubantu.
I-CUMYL-4CN-BINACA yenziwe nge-metabolized ukuze ikhiqize i-cyanide, iphakamisa ukukhathazeka ngobuthi besibindi.Kube necala elilodwa elibikiwe le-hyperthermia, i-rhabdomyolysis kanye nokwehluleka kwezinso okuhambisana nokusetshenziswa kwayo.