Izithako Zemithi Esebenzayo I-Steroids Sarms CAS 595-33-5 Megestrol acetate
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Ulwazi Oluyisisekelo
I-Megestrol Acetateuhlobo lukasawoti we-acetate lwe-megestrol, okuphuma kokwenziwa kwe-progesterone yehomoni yobulili yowesifazane eyenzeka ngokwemvelo enamandla okulwa ne-estrogenic kanye nomsebenzi we-antineoplastic.
Isetshenziswa kaningi ekwelapheni iziguli ezinomdlavuza webele we-metastatic.Ngokuvamile kubekezelelwa kahle, ngaphandle kokuthi kungase kubangele ukuzuza kwesisindo esingathandeki.Kamuva, kwaboniswa ukuthi i-megestrol acetate ikhiqize ukuzuza kwesisindo ezinhlobonhlobo zeziguli ezinomdlavuza we-cachectic.
Amazinga e-inserum ancishisiwe kakhulu we-IL-1a kanye ne-b, IL-2, IL-6, ne-TNF-o abonwe ezigulini ezinomdlavuza elashwe nge-megestrol acetate engase ibhekane nendlela yokuthuthukisa isifiso sokudla kanye nokuzuza kwesisindo somzimba. ukuthi umphumela, okungenani ngokwengxenye, uqondiswa yi-NPY, isivuseleli esinamandla sokudla.
Ukusetshenziswa
1. I-Megestrol acetate USP (Megace)isetshenziselwa ukwelapha i-Carcinoma yebele noma i-endorometrium.
2. I-Megestrol acetate (Megace), i-semi-synthetic progestational steroid, iyisikhuthazi sesifiso sokudla esaziwa kakhulu njengamanje.Ngaphambilini esetshenziselwa iziguli ezinomdlavuza kanye ne-immunodeficiency syndrome, izifundo ezimbalwa kuphela eziye zacabangela ukusebenza kwalesi sidakamizwa kubantu asebekhulile abangondlekile.
I-Megestrol acetate iwusizo uma i-anorexia ejulile iwukubonakaliswa okuyinhloko kwe-cachexia futhi uma kulindelekile ukusinda kungamasonto kuya ezinyangeni.I-Megace iboniswe ukuthi ikhulisa kakhulu isifiso sokudla, kodwa hhayi ukusinda.Ezigulini ezinokusinda okufushane okubikezelwe, inkambo emfushane ye-corticosteroids ingase ibe usizo ekuvuseleleni isifiso sokudla futhi ibe nemiphumela emihle ekucanuleni, ubuhlungu, kanye ne-asthenia.
Incazelo evamile
I-17-hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate(Megace), iyi-progestin esetshenziswa ngokuyinhloko ekulawuleni ukwelapha kwe-recurrent, engasebenzi, noma i-metastatic endometrialor breast carcinoma.I-Megestrol acetate nayo ikhonjiswe ukuthuthukisa isifiso sokudla ezigulini ezine-AIDS.Isisekelo se-biochemical salokhu kusetshenziswa kwe-megestrol asicacile.
Ukusetshenziswa KwezokwelaphaUmsebenzi we-Progestin uthuthukiswa nakakhulu lapho isibopho esiphindwe kabili sethulwa phakathi kwezikhundla 6 kanye ne-7, njengoba kutholakala ku-megestrol acetate.I-Megestrol isetshenziswa ngokuyinhloko ekwelapheni umdlavuza webele kanye ne-endometrial kanye nakwabesifazane abangemva kokuya esikhathini abane-carcinoma encike ku-hormone ethuthukisiwe.
Iphrofayela YokuphephaI-carcinogen esolwayo enedatha yokuhlola ye-carcinogenic ne-teratogenic.Ubuthi ngomzila we-intravenous.Imiphumela yokuzala komuntu yokungenisa i-bp nezindlela zokufakelwa: imiphumela kuma-ovari namashubhu e-fallopian, izinguquko zomjikelezo wokuya esikhathini, kanye nezinguquko zenkomba yokuzala kwabesifazane.Idatha yokuguquguquka ibikiwe.Imiphumela yokuhlola yokuzala.Uma ishiselwa ukuze ibole ikhipha intuthu emuncu kanye nentuthu ecasulayo.Umuthi osemthethweni we-FDA osetshenziselwa ukwelapha i-endometriosis nomdlavuza webele.I-steroid.