Xylazine CAS RỌ: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Lilo oogun
Toluene thiazide ni a lo nigbagbogbo bi sedative, isinmi iṣan ati analgesic.Nigbagbogbo a lo lati ṣe itọju tetanus.Xylazine jọra pupọ si awọn oogun bii phenothiazine, awọn antidepressants tricyclic ati clonidine.Gẹgẹbi anesitetiki, igbagbogbo lo ni apapo pẹlu ketamine.Xylazine han lati dinku ifamọ ti ara si hisulini ati gbigba glukosi.Yohimbine jẹ alpha2 adrenergic antagonist olugba ti a ti lo lati dinku awọn ipele glukosi si awọn ipele ilera.Yohimbine yi awọn ipa ẹgbẹ ti toluene thiazide pada ni eto ile-iwosan ti a ba nṣakoso ni iṣan ni kete lẹhin ti a ti nṣakoso toluene thiazide.

pharmacodynamics

Xylazine jẹ alpha 2 adrenergic agonist ti o lagbara.Toluene thiazide ati awọn agonists olugba alpha2 adrenergic miiran ti pin jakejado ara laarin awọn iṣẹju 30-40 nigba fifun.Nitori lipophilicity giga rẹ, toluene thiazide taara nfa awọn olugba α2 aarin bi daradara bi awọn olugba αadrenergic agbeegbe ni ọpọlọpọ awọn ara.Gẹgẹbi agonist, toluene thiazide ṣe abajade ni idinku neurotransmission ti norẹpinẹpirini ati dopamine ninu eto aifọkanbalẹ aarin.O ṣe bẹ nipa ṣiṣafarawe ìde norẹpinẹpirini si awọn olutẹtisi autoreceptors lori dada presynapti, eyiti o fa idinamọ esi ti norẹpinẹpirini.

Xylazine tun ṣe bi oludena gbigbe nipasẹ didaduro iṣẹ gbigbe norẹpinẹpirini nipasẹ ifigagbaga ni idinamọ gbigbe gbigbe sobusitireti.Nitorinaa, toluene thiazide pọ si ni pataki K m ati pe ko kan V max.Eyi le waye nipasẹ ibaraenisepo taara pẹlu awọn agbegbe ti o ni lqkan pẹlu awọn aaye abuda antidepressant.Fun apẹẹrẹ, toluene thiazide ati clonidine ṣe idiwọ gbigba MIBG (afọwọṣe norẹpinẹpirini) nipasẹ awọn sẹẹli neuroblastoma.Xylazine ni awọn ibatan oriṣiriṣi fun cholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, ati awọn olugba opioid.Ilana kemikali rẹ jọra pupọ si ti phenothiazines, awọn antidepressants tricyclic ati clonidine.