Peptide ifun inu Vasoactive CAS: 40077-57-4 PEPTIDE INU VASOACTIVE, PORCINE VASOACTIVE INU PEPTIDE

Awọn peptides intestinal Vasoactive, ti a tun mọ ni awọn peptides intestinal vasoactive tabi VIP, jẹ awọn homonu peptide ti o jẹ vasoactive ninu ikun.VIP jẹ peptide kan ti o ni awọn iṣẹku amino acid 28 ti o jẹ ti glucagon/secretin superfamily ati pe o jẹ ligand ti Class II G protein-coupled awọn olugba.VIP jẹ iṣelọpọ ni ọpọlọpọ awọn iṣan vertebrate, pẹlu ikun, pancreas, ati arin suprachiasmatic ti hypothalamus ọpọlọ.VIP ṣe idawọle iṣọn-ọkan ọkan, fa vasodilation, mu idinku glycogen pọ si, dinku titẹ ẹjẹ iṣọn-ẹjẹ ati ki o sinmi awọn iṣan didan ninu trachea, ikun ati gallbladder.Ninu eniyan, awọn peptides oporoku vasoactive jẹ koodu nipasẹ awọn Jiini VIP.

Igbesi aye idaji (t ½) ti VIP ninu ẹjẹ jẹ bii iṣẹju meji.

VIP ni ipa lori ọpọlọpọ awọn ajo:

Ninu eto ti ngbe ounjẹ, VIP han lati fa isinmi ti iṣan dan (sfincter esophageal isalẹ, ikun, gallbladder), ṣe itọsi omi sinu ito pancreatic ati bile, ati ṣe idiwọ yomijade ati gbigba acid gastric lati inu iho inu.Ipa rẹ ninu ifun ni lati ṣe alekun yomijade ti omi ati awọn elekitiroti pupọ, bi daradara bi sinmi iṣan didan ifun, dilate awọn ohun elo ẹjẹ agbeegbe, mu yomijade ti bicarbonate silẹ nipasẹ oronro ati ṣe idiwọ yomijade acid itusilẹ gastrin.Awọn ipa wọnyi ṣiṣẹ papọ lati mu motility pọ si.O tun nmu yomijade ti pepsinogen ṣiṣẹ nipasẹ sẹẹli akọkọ.VIP han lati jẹ neuropeptide ti o ṣe pataki lakoko arun ifun iredodo nitori sẹẹli mast ati ibaraẹnisọrọ VIP ti wa ni atunṣe ni colitis gẹgẹbi arun Crohn.

O tun wa ninu ọkan ati pe o ni ipa pataki lori eto inu ọkan ati ẹjẹ.O fa vasodilation iṣọn-alọ ọkan ati pe o ni inotropic rere ati awọn ipa chronotropic.Iwadi n lọ lọwọ lati pinnu boya o ni ipa anfani ni itọju ikuna ọkan.VIP ṣe iwuri lubrication abẹ ni awọn obinrin deede, ilọpo meji iye iye lubrication ti a ṣe