Clobetasol propionate le ṣe itọju si psoriasis?Gbogbo awọn arun awọ ara ti o wọpọ?

Clobetasol propionatele ṣe itọju psoriasis.

Awọn itumọ ọrọ sisọ:

17-propionate; cgp9555; Clobetasol 17-propionate ojutu,100ppm;Cloβsol propionate;21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propoonate; CLOBETASOL 17-PROPIONATE USP; -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate; Dermovat

Lilo:

Clobetasol Propionatejẹ fọọmu iyọ propionate ti clobetasol, corticosteroid sintetiki ti agbegbe pẹlu egboogi-iredodo, egboogi-pruritic, ati awọn ohun-ini vasoconstrictive.Clobetasol propionate n ṣiṣẹ ipa rẹ nipa dipọ si awọn olugba glucocorticoid cytoplasmic ati lẹhinna mu ikosile jiini ti olugba olugba glucocorticoid ṣiṣẹ.Eyi ni abajade ni iṣelọpọ ti awọn ọlọjẹ egboogi-iredodo kan, lakoko ti o dẹkun iṣelọpọ ti awọn olulaja iredodo kan.Ni pataki, clobetasol propionate han lati fa awọn ọlọjẹ inhibitory phospholipase A2, nitorinaa iṣakoso itusilẹ ti arachidonic acid ti o ni iredodo lati inu phospholipids awo nipasẹ phospholipase A2.

Clobetasol propionate jẹ 17-O-propionate ester ti clobetasol ati pe o ni lati inu clobetasol ati propionic acid.Corticosteroid ti o lagbara, a lo lati tọju ọpọlọpọ awọn rudurudu awọ, pẹlu exzema ati psoriasis.
Clobetasol propionate jẹ itọsi ni 1968 o si wa sinu lilo iṣoogun ni 1978. O wa bi oogun jeneriki.Clobetasol propionate ti wa ni lilo fun awọn itọju ti awọn orisirisi awọn rudurudu awọ ara pẹlu àléfọ, Herpes labialis, psoriasis, ati lichen sclerosus.A tun lo lati ṣe itọju ọpọlọpọ awọn arun ajẹsara ara-ara, pẹlu alopecia areata, lichen planus (awọn nodules awọ ara ajẹsara), ati awọn fungoides mycosis (Lymphoma skin skin T-cell).O ti wa ni lo bi akọkọ-ila itọju fun awọn mejeeji ńlá ati onibaje GVHD ti awọn awọ ara.Clobetasol propionate (Cormax, Temovate, Embeline, Olux) jẹ ọkan ninu awọn ti o lagbara julọ ti awọn aṣoju ti o wa lọwọlọwọ ati pe o jẹ itọkasi fun itọju igba diẹ ti iredodo. tabi awọn rudurudu hyperplastic.O jẹ corticosteroid sintetiki fluorinated.O le fa idahun ti o yara diẹ sii tabi gigun ju awọn corticosteroids agbegbe miiran lọ.A ṣe iṣeduro pe clobetasol ni ohun elo ti o pọju ti 60 g / ọsẹ fun ko ju ọjọ 14 lọ laisi idinamọ ati pe ko yẹ ki o lo ninu awọn ọmọde labẹ ọdun 12.

Ojutu ti betamethasone 21-methanesulfonate (4 g) ni dimethylformamide (25 milimita) ni a tọju pẹlu lithium kiloraidi (4 g) ati adalu kikan lori iwẹ nya si fun ọgbọn išẹju 30.Dilution pẹlu omi fun awọn robi ọja ti o ti recrystallized lati irewesi akole yellow, MP 226°C.
Clobetasol maa n yipada si propionate bi fọọmu ti o wulo nipasẹ iṣesi pẹlu propionic anhydride.