Larazotide acetate CAS 881851-50-9
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Iwa:
| wọpọ orukọ | Larazotide acetate | English orukọ | Larazotide acetate |
|---|---|---|---|
| nọmba CAS | 881851-50-9 | iwuwo molikula | 785.88500 |
| molikula agbekalẹ | C34H59N9O12 |
|---|
| ibi-pipe | 785.42800 |
|---|---|
| PSA | 360.55000 |
| LogP | 3.73650 |
Lilo:
Larazotide acetate jẹ oogun olutọsọna isunmọ ifun inu, ti a mọ tẹlẹ bi Innovate Biopharmaceuticals ṣaaju iṣọpọ kan, eyiti o ni idanwo lọwọlọwọ ni awọn alaisan agbalagba ti o ni arun celiac ni idanwo ile-iwosan alakoso III.peptide pq ẹyọkan yii jẹ yo lati zonulin eniyan, modulator ti a mọ ti aiṣedeede junction ti o ni ikosile ti ara inu ifun ni awọn alaisan ti o ni arun celiac.LA tun pin awọn ibajọra igbekalẹ si Vibrio cholerae zonula occludens toxin (Zot), eyiti o jẹ enterotoxin kan ti o fa idamu ilana isunmọ isunmọ intercellular nipasẹ polymerization actin ati awọn iyipada cytoskeletal ti o ja si ni alekun permeability oporoku nipasẹ ami ifihan intracellular.Botilẹjẹpe LA ti ṣe afihan ileri ni awọn idanwo ile-iwosan fun awọn alaisan ti o ni arun celiac, awọn iwadii aipẹ ti o lo ọpọlọpọ awọn awoṣe ipalara ẹranko tọkasi lilo ti o pọju fun LA fun awọn arun miiran nitori agbara rẹ lati ṣe ilana awọn ipadapọ to muna.Atunyẹwo kekere yii ni ero lati pese orisun alaye ti alaye lọwọlọwọ lori octapeptide yii.
