China Gbona Tita CAS 2894-68-0 Diclazepam
Kemikalaworan atọka
Awọn itumọ ọrọ sisọ
2-chlorodiazepam;
1-Methyl-7-chloro-5- (2-chlorophenyl) -1,3-dihydro-2H-1,4-benzodiazepine-2-ọkan;
1-Methyl-7-chloro-5- (2-chlorophenyl) -1H-1,4-benzodiazepine-2 (3H) -ọkan;
7-Chloro-5- (2-chlorophenyl) -1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-ọkan;
o-Chlorodiazepam;
Ro 5-3448;
DiclazepaM;
2H-1,4-Benzodiazepin-2-ọkan,7-chloro-5-(2-chlorophenyl)-1,3-dihydro-1-Methyl-
Apejuwe
Diclazepam, ti a tun mọ ni 2-chlorodiazepam ati chlorodiazepam, jẹ ipin ninu idile benzodiazepam, ati pe o jẹ analogue diazepam kan. Leo Sternbach ati ẹgbẹ rẹ ni akọkọ ti ṣajọpọ rẹ ni Hoffman-La Roche ni ọdun 1960, ṣugbọn ko lepa bi elegbogi product.Diclazepam doseji, ipa tabi ailewu ninu eda eniyan ti kò a formally iwadi.Ninu awọn ẹranko, sibẹsibẹ, o mọ lati ni awọn ipa ti o jọra pupọ si flubromazepam ati diazepam funrararẹ.Awọn ipa rẹ pẹlu ṣiṣẹ bi anticonvulsant ati anxiolytic, sedative, hypnotic, amnesiac ati bi isinmi isan iṣan.O le ni awọn ipa ti ko dara gẹgẹbi irọra, ati awọn ailagbara imọ gẹgẹbi aipe iranti igba kukuru.
Diclazepam ti ṣe ayẹwo bi nini imukuro idaji-aye ti o wa ni ayika awọn wakati 42 ni ọpọlọpọ awọn ẹranko.Ninu ara, o faragba N-demethylation, Abajade ni awọn ẹda ti delorazepam.A le rii delorazepam ninu ito koko-ọrọ fun isunmọ ọjọ mẹfa.O tun metabolizes sinu lormetazepam (awari fun 19 ọjọ) ati lorazepam (awari fun 11 ọjọ).Eyi ni imọran pe awọn enzymu cytochrome P450 tun n ṣe alabapin ninu hydroxylation ti agbo ni akoko kanna bi N-demethylation.
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