Awọn ohun elo Kemikali Anesitetiki Awọn oogun iranlọwọ CAS 59-46-1 PROCAINE
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Alaye ipilẹ
Apejuwe
Procaine jẹ anesitetiki agbegbe pẹlu iṣẹ para-amino kan.Ifamọ nipataki awọn ifiyesi iṣoogun, ehín ati awọn oojọ ti ogbo.
Kemikali Properties
Iyo hydrochloride ti 2- (diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 tabi N2C6H4COOCH2CH2NH(C2H5)2HCl) ni gbogbo igba tọka si bi procaine.Botilẹjẹpe ester PABA jẹ insoluble ninu omi, iyọ hydrochloride jẹ tiotuka pupọ ninu omi.
Nlo
1.Procaine (Novocain) jẹ lilo akọkọ ni ehín tabi awọn ilana iṣoogun ti o nilo akuniloorun infiltration, bulọọki agbeegbe, tabi bulọki ọpa ẹhin.
2.inhibitor ti ikanni soda
3. Procaine jẹ oludena ikanni iṣuu soda ati oludena ti awọn ilana ti o yatọ.
Lilo
Isẹgun LiloProcaine ni kiakia metabolized ninu pilasima nipasẹ cholinesterases ati ninu ẹdọ nipasẹ ester hydrolysis nipasẹ pseudocholinesterase.Igbesi aye idaji ninu vitroelimination jẹ isunmọ awọn aaya 60.Eyikeyi ipo ti o dinku ifọkansi cholinesterase le ṣe alekun ifihan si procaine ati majele ti o pọju.Iṣẹ ṣiṣe Decreasedenzyme ni a le rii pẹlu aipe jiini, aarun ẹdọ, aijẹ, aijẹununjẹ, ikuna kidirin, gbigbona, oṣu kẹta ti oyun, ati atẹle abẹ-alọ ọkan ọkan.Ester hydrolysis ṣe agbejade PABA, yellow lodidi fun awọn aati inira ti o wọpọ si awọn anesitetiki theester.A ko lo Procaine ni oke nitori ailagbara lati kọja nipasẹ awọn membran ọra ati pe o rii lilo bi oluranlowo imunifun fun awọ-ara tabi awọn membran mucous, awọn ilana kukuru.A tun lo Procaine fun igbẹgbẹ nerveblock ati bi oluranlowo epidural lati ṣe iwadii awọn iṣọn-ara irora.