Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Ukusetyenziswa kwezonyango
I-Toluene thiazide isetyenziswa ngokuqhelekileyo njenge-sedative, i-muscle relaxant kunye ne-analgesic.Ihlala isetyenziselwa ukunyanga itetanus.I-Xylazine ifana kakhulu neziyobisi ezifana ne-phenothiazine, i-tricyclic antidepressants kunye ne-clonidine.Njenge-anesthetic, isoloko isetyenziswa ngokudibanisa ne-ketamine.I-Xylazine ibonakala inciphisa ukuvakalelwa komzimba kwi-insulin kunye ne-glucose.I-Yohimbine i-alpha2 i-adrenergic receptor antagonist esetyenziselwe ukunciphisa amanqanaba e-glucose kumanqanaba aphilileyo.I-Yohimbine ibuyisela umva iziphumo ebezingalindelekanga ze-toluene thiazide kwimeko yeklinikhi ukuba ilawulwa ngomthambo kamsinya nje emva kokuba i-toluene thiazide ilawulwe.

i-pharmacodynamics

I-Xylazine yi-agonist enamandla ye-alpha 2 ye-adrenergic.I-Toluene thiazide kunye nezinye i-alpha2 adrenergic receptor agonists zisasazwa kuwo wonke umzimba ngaphakathi kwe-30-40 imizuzu xa zinikezelwe.Ngenxa ye-lipophilicity ephezulu, i-toluene thiazide ivuselela ngokuthe ngqo i-α2 receptors ephakathi kunye ne-peripheral αadrenergic receptors kwiintlobo ezahlukeneyo zezicubu.Njenge-agonist, i-toluene thiazide iphumela ekunciphiseni ukuhanjiswa kwe-neurotransmission ye-norepinephrine kunye ne-dopamine kwinkqubo ye-nervous central.Ikwenza oko ngokulinganisa ukubophelela kwe-norepinephrine kwi-autoreceptors kwi-presynaptic surface, ebangela ukuvinjelwa kwempendulo ye-norepinephrine.

I-Xylazine iphinda isebenze njenge-inhibitor yezothutho ngokuvimbela umsebenzi wezothutho we-norepinephrine ngokukhuphisana ngokuthintela ukuthuthwa kwe-substrate.Ngaloo ndlela, i-toluene thiazide inyuse kakhulu i-K m kwaye ayizange ichaphazele i-V max.Oku kunokwenzeka ngonxibelelwano oluthe ngqo kunye nemimandla edibana neziza ezibophelelayo zokuthomalalisa uxinzelelo.Ngokomzekelo, i-toluene thiazide kunye ne-clonidine inqanda ukufunyanwa kwe-MIBG (i-norepinephrine analogue) ngeeseli ze-neuroblastoma.I-Xylazine ine-affinities eyahlukeneyo ye-cholinergic, i-serotonergic, i-dopaminergic, i-alpha1, i-adrenergic, i-H 2-histamine, kunye ne-opioid receptors.Ubume bayo beekhemikhali bufana kakhulu ne-phenothiazines, i-tricyclic antidepressants kunye ne-clonidine