I-Vasoactive Intestinal Peptide CAS:40077-57-4 I-VASOACTIVE INTESTINAL PEPTIDE, IPORCINE VASOACTIVE INTESTINAL PEPTIDE

inkcazelo emfutshane:

INOMBOLO YECASS:40077-57-4

Igama:I-Vasoactive Intestinal Peptide

Ifomula yemichiza:I-C147H238N44O42S

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Ukusetyenziswa

I-Vasoactive intestinal peptides, eyaziwa ngokuba yi-vasoactive intestinal peptides okanye i-VIP, ziihomoni ze-peptide ezine-vasoactive emathunjini.I-VIP yi-peptide equkethe i-28 amino acid iintsalela ze-glucagon / i-secretin superfamily kwaye i-ligand ye-Class II G i-protein-coupled receptors.I-VIP iveliswa kwiithishu ezininzi ze-vertebrate, kubandakanywa amathumbu, i-pancreas, kunye ne-suprachiasmatic nucleus ye-hypothalamus yobuchopho.I-VIP ivuselela ukuqina kwentliziyo, ibangela i-vasodilation, inyusa ukuphuka kwe-glycogen, ithobe uxinzelelo lwegazi kunye nokukhulula izihlunu ezigudileyo kuqhoqhoqho, isisu kunye ne-gallbladder.Ebantwini, i-vasoactive intestinal peptides ifakwe kwiikhowudi ze-VIP.

Ubomi besiqingatha (t ½) beVIP egazini bumalunga nemizuzu emibini.

I-VIP inefuthe kwimibutho eyahlukeneyo:

Kwinkqubo yokugaya, i-VIP ibonakala ibangela ukuphumla kwe-muscle egudileyo (i-low esophageal sphincter, isisu, i-gallbladder), ivuselela ukukhuselwa kwamanzi kwi-pancreatic fluid kunye ne-bile, kwaye inqanda ukukhupha kunye nokufunxa kwe-asidi yesisu kwi-intestinal cavity.Indima yayo emathunjini kukukhuthaza kakhulu ukukhuselwa kwamanzi kunye ne-electrolytes, kunye nokuphumza izihlunu ezigudileyo zamathumbu, ukunweba imithambo yegazi yeperipheral, ukuvuselela ukukhutshwa kwe-bicarbonate yi-pancreas kunye nokuthintela ukukhuselwa kwe-asidi ye-gastrin.Ezi ziphumo zisebenza kunye ukwandisa i-motility.Ikwavuselela ukukhuselwa kwe-pepsinogen yiseli engundoqo.I-VIP ibonakala iyi-neuropeptide ebalulekileyo ngexesha lokudumba kwesifo ngenxa yokuba i-mast cell kunye ne-VIP yonxibelelwano ilawulwa kwi-colitis efana nesifo sika-Crohn.

Ikwakhona entliziyweni kwaye inefuthe elibonakalayo kwi-cardiovascular system.Ibangela i-coronary vasodilation kwaye ibe nemiphumo emihle ye-inotropic kunye ne-chronotropic.Uphando luyaqhubeka ukufumanisa ukuba lunesiphumo esiluncedo ekunyangeni ukusilela kwentliziyo.I-VIP ivuselela i-lubrication ye-vaginal kubasetyhini abaqhelekileyo, iphinda kabini isixa esipheleleyo sokuthambisa esiveliswayo