Somatostatin CAS: 51110-01-1 panhibin Anti-Somatostatin UMNTU, OVINE PORCINE RAT MOUSE 2ACOH 6H2O

I-Somatostatin, eyaziwa ngokuba yi-hormone yokukhula ye-hormone suppressor (GHIH) okanye amanye amagama amaninzi, i-hormone ye-peptide elawula inkqubo ye-endocrine kwaye ichaphazela ukuhanjiswa kwe-neurotransmission kunye nokwanda kweeseli ngokusebenzisana ne-G-protein-coupled somatostatin receptors kunye nokuvimbela ukukhululwa kweentlobo ezahlukeneyo. iihomoni.Iihomoni zesibini.I-Somatostatin inqanda i-insulin kunye ne-glucagon secretion.

I-Somatostatin iza kwiifom ezimbini ezisebenzayo, eziveliswa ngokutshintshisa ukusika kwe-progenin enye: enye iqukethe i-amino acids ye-14 (eboniswe kwibhokisi yolwazi ngakwesokudla), kwaye enye iqulethe i-28 amino acids.

Kwizilwanyana ezinomqolo, kukho iintlobo ezintandathu ezahlukeneyo ze-somatostatin, ezibizwa ngokuba yi-SS1, SS2, SS3, SS4, SS5, kunye ne-SS6.I-Zebrafish inazo zontandathu.Iijeni ezintandathu ezahlukeneyo, kunye ne-somatostatin receptors ezihlanu ezahlukeneyo, zinika i-somatostatin uluhlu olubanzi lwemisebenzi.Abantu bane-somatostatin gene kuphela, i-SST.

inkqubo yokwetyisa
I-Somatostatin ifihliwe ngamaseli e-delta kwiindawo ezininzi kwi-digestive system, ezizezi pyloric sinuses, duodenum, kunye ne-islets.

I-Somatostatin ekhutshwe yi-pyloric sinuses ingena entliziyweni ngokusebenzisa inkqubo ye-portal kwaye ingena kwi-systemic circulation kwindawo yokuvimbela.Ukongeza, i-somatostatin ekhutshwe ngamaseli e-δ inokusebenza ngendlela yeparacrine.

Kwisisu, i-somatostatin isebenza ngokuthe ngqo kwiiseli ze-parietal ezivelisa i-asidi ngokusebenzisa i-G-protein-coupled receptors (evimbela i-adenylate cyclase kwaye ngaloo ndlela ichasene ngokufanelekileyo nokuvuselela i-histamine) ukunciphisa ukukhutshwa kwe-asidi yesisu.I-Somatostatin iphinda ibambe ngokufanelekileyo inkqubo yokugaya ngokunciphisa ngokungangqalanga ukuveliswa kwe-asidi yesisu ngokuthintela ukukhululwa kwamanye amahomoni afana ne-gastrin kunye ne-histamine.