SARM SR9011 Pharmaceutical Raw Powder for Boosting Exercise Endurance CAS 1379686-30-2

SARM SR9011 Pharmaceutical Raw Powder for Boosting Exercise Exercise CAS 1379686-30-2 Image Featured

inkcazelo emfutshane:

Inkcazo yeMveliso eneenkcukacha

Igama lemveliso:SR9011
Iimveliso ezinxulumeneyo:SR9009
I-CAS:1379686-29-9
Imbonakalo:Umgubo oMhlophe
Ukusetyenziswa:Ukwakhiwa Kwezihlunu
Uhlobo lokuqhuba ngenqanawe:EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
Ukukhanya okuphezulu:isarms bodybuilding supplements, sarms steroids

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

SR9011 Iinkcukacha eziKhawulezayo

Inombolo yeCas 1379686-29-9
Izithethantonye 3-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Ifomula yeC23H31ClN4O3S
Ubunzima beMolucelar 479.03524

SR9011Inkcazo

I-SR9011 yi-monomer ye-methacrylate esebenza kathathu ebonelela ngokuncamathela okukhethekileyo kwintsimbi.
substrates.

I-SR9011 iyacetyiswa ukuba isetyenziswe kwiingubo ezinyangekileyo zeperoxide, izitywini, kunye neeplastisol ezisekwe kwiPVC.
Amanqanaba okusetyenziswa kwe-5% ukuya kwi-10% ngesisindo siyacetyiswa.

I-SR9011 yi-REV-ERB enamandla kwaye ikhethekileyo.Ikwanayo ne-vivo plasma/exposure yengqondo.
Izamkeli zenyukliya REV-ERB-α kunye neREV-ERB-β zidlala indima ebalulekileyo ekulawuleni intetho.
yeeprotheyini zewotshi eziphambili, izigqi zokuqhuba kumsebenzi kunye nemetabolism.Ulawulo lweenguqu ze-SR9011
Ukuziphatha kwe-circadian kunye nepateni ye-circadian ye-core clock gene expression kwi-hypothalami yeempuku.
Ipatheni yokubonisa i-circadian yoluhlu lweejini ze-metabolic esibindini, kwisihlunu samathambo kunye
Izicubu ze-adipose nazo zatshintshwa, okubangele ukwanda kwenkcitho yamandla.Unyango lwe-diet-induced
iimpuku ezityebileyo ezine-SR9011 zehlise ukutyeba ngokunciphisa ubunzima bamafutha kunye nokuphucula ngokuphawulekayo i-dyslipidaemia kunye ne-hyperglycaemia.Ezi ziphumo zibonisa ukuba ii-ligands ze-REV-ERB zokwenziwa ezijolise kwi-pharmacologically
isigqi se-circadian sinokuba luncedo kunyango lweengxaki zokulala kunye nezifo ze-metabolic.

Isetyenziswa njani i-SR9011?

I-In vitro: I-SR9011 isetyenziswe kwi-5-10 μM yoxinaniso kwi-vitro kunye nakwiimvavanyo zeselula.
Kwi-vivo: Ulawulo lwe-IP lwe-SR9011 lusetyenziswe kwi-100 mg / kg kanye okanye kabini ngosuku kwi-12-30
iintsuku kwiimodeli ezahlukeneyo mouse.

Udibaniso lwe-SR9009 kunye ne-SR9011

Iikhompawundi zenziwe nge-amination yokunciphisa i-5-nitro-2-thiophenecarboxaldehyde kunye ne-4-chlorobenzylamine kunye ne-sodium triacetoxyborohydride ivelise i-amine yesibini.I-amination yesibini yokunciphisa kunye ne-1-Boc-pyrrolidine-3-carboxaldehyde ivelise i-amine ephezulu.Le khompawundi iphathwe nge-trifluoroacetic acid ukususa iqela lokukhusela i-Boc, kwaye emva koko iphendule nokuba yi-ethyl chloroformate (SR9009) okanye i-pentyl isocyanate (SR9011) ukunika iimveliso ezifunwayo.

SR9011I-COA

Into	Inkcazo	Isiphumo
Imbonakalo	Umgubo ongenavumba, phantse omhlophe okanye omhlophe	dlula
Isazisi	Ixesha lokugcinwa kwencopho enkulu qinisekisa kwi-RS	dlula
Ilahleko ekomisweni	Akukho ngaphezu kwe-0.5%	0.33%
Uvavanyo(HPLC)	Hayi ngaphantsi kwe 99.0%	99.59%
Intsalela yokutshisa	Akukho ngaphezu kwe-0.1%	dlula
Intsimbi enzima	Akukho ngaphezu kwe-20 ppm	dlula