amayeza aphakathi kwe-99% yokucoca umgubo CAS 86386-73-4 Fluconazol
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Ulwazi olusisiseko
I-Fluconazole-D4 ibonakala imhlophe ukuya kumgubo wekristale otyheli-mhlophe kwaye inevumba elincinane kunye nencasa ekrakra.
Inyibilika ngokulula kwiglacial acetic acid, methanol okanye ethanol, ayinyibiliki emanzini kwaye phantse ayinyibiliki kwi-ether nendawo yokunyibilika ibe yi-137~141.6 ℃, okanye indawo yokunyibilika ibe yi-138~140 ℃ (iphuma kwi-ethyl acetate-hexane).
Ukusetyenziswa
Le mveliso yeye-fluorinated triazole ichiza le-antifungal kunye ne-antifungal spectrum efana ne-ketoconazole kodwa umsebenzi we-antifungal uphezulu kune-ketoconazole.
Indlela yokusebenza kwayo kukuthintelwa kwecandelo elibalulekileyo le-membrane yeseli yefungal, i-ergosterol biosynthesis enzyme, ukuthintela i-ergosterol synthesis kunye nokwaphula ingqibelelo yodonga lweseli lomngundo, luthintela ngakumbi ukukhula kunye nokuzala.
Imveliso inomsebenzi onamandla we-antifungal ngokumelene ne-Candida albicans, i-Microsporum canis, i-Cryptococcus neoformans, i-histoplasma capsulatum kunye ne-epidermophyton.
Iipropati zeMichiza
I-Fluconazole-D4 iMhlophe ukuya kuMhlophe-Okuqinileyo
Isebenzisa iLebhile iFluconazole (F421000).Isetyenziswa njenge-antifungal.
Isebenzisa i-anticholinergic
Isebenzisa iFluconazole-D4 isetyenziselwa unyango lwezifo zokungunda.
Isebenzisa i-Agent ye-triazole ebanzi ye-antifungal.
Iimpawu
I-Fluconazole (i-Diflucan) inokufunxwa ngcono kwaye mhlawumbi ingaphantsi kwe-hepatotoxic kune-ketoconazole, kodwa ibiza kakhulu, uqwalaselo olubalulekileyo olunikezwa ubude obufunekayo bonyango kwizifo ezininzi zokungunda.