I-Nimetazepam CAS: i-2011-67-8 i-hypnotic tranquilizer

I-Nimetazepam yi-hypnotic esebenzayo ephakathi, i-benzodiazepine derivative.Yaqala ukwenziwa ngo-1964 liqela likaHoffmann-La Roche.Ine-hypnotic enamandla, i-anti-anxiety, izolile kunye nemiphumo yokuphumla kwemisipha yamathambo.I-Nimetazepam ikwayi-anticonvulsant esebenzayo ngokukodwa.Ithengiswa njenge-tablet ye-5-milligram ebizwa ngokuba yi-Erimin, igama le-brand elenziwe kwaye lithengiswa ngu-Sumitomo, inkampani enkulu yaseJapan.IJapan kuphela kwelizwe elivelisa i-nimetazepam emhlabeni.Ngaphandle kweJapan, i-Erimin ifumaneka kwiindawo ezininzi zaseMpuma nakumazantsi-mpuma e-Asia kwaye isetyenziswa ngokubanzi njengonyango lwexesha elifutshane kubantu abanengxaki yokungalali ngokwaneleyo abafumana kunzima ukulala okanye ukulala.I-Sumitomo iyekile ukwenza i-Erimin ukususela ngoNovemba 2015. Isafumaneka njengegeneric okanye iLavol.

I-Nimetazepam yayimiselwe ngokubanzi kwi-1980 kunye ne-1990, ngokukodwa eJapan, eMalaysia, eBrunei, kwiiPhilippines, eThailand, e-Indonesia, eHong Kong naseSingapore.Ngokuxhaphazwa kunye nokulutha kuxhaphakile, imimiselo yesiyobisi iye yawa kakhulu ukususela ngo-2005. Isetyenziswa ngokuyintloko njenge-anticonvulsant ebantwaneni.Ikwasetyenziswa kwezona meko zinzima nezidodobalisayo zokungalali kwiiSetingi zezigulana ezilaliswayo okanye unyango lwexeshana elifutshane.Ngenxa yale njongo, iipilisi zokulala ze-benzodiazepines Esazolam kunye ne-nitrazepam zazisetyenziswa rhoqo kune-nitrazepam.Ii-Antidepressants ezifana ne-trazodone kunye ne-mirtazapine okanye i-Zopiclone kunye ne-zolpidem ngamayeza omgca wokuqala wokuphuthelwa.

Nangona ummiselo we-nimetazepam wehlile, ukusetyenziswa kakubi kwechiza kuhlala kuphezulu eBrunei, eSingapore, eMalaysia nasePhilippines.Idla ngokusetyenziswa ngokudibeneyo ne-methamphetamine kunye ne-ecstasy, kunye nee-opioids (ingakumbi i-heroin okanye i-morphine).I-Nimetazepam iphantsi kwezithintelo ezingqongqo ezisemthethweni eMalaysia, ezenze ichiza lanqongophala, kodwa uninzi lweepilisi ezithengiswa kwimarike emnyama phantsi kwegama elithi Nimetazepam zezomgunyathi.I-Diazepam kunye ne-nitrazepam zezinye zezona ziqhelekileyo zisetyenziswa kwi-benzodiazepines kulo mmandla, kwaye ngenxa yoko, zihlala ziphambukiswa kwaye zithengiswa kwimarike emnyama, rhoqo njenge-nitrazepam.

Ukuveliswa ngokungekho mthethweni kweNimezepam (ethengiswa njenge-Erimin-5) ixhaphake kakhulu kummandla.Ukuxhatshazwa kwe-nimetazepam kwaqhubeka kwanda kuyo yonke i-2010s.Ukuxhuzulwa kweetafile ezenziwe ngokungekho mthethweni ze-Erimin-5 ezihambelana nokubanjwa kwe-methamphetamine eMalaysia.Inani elincinane leepilisi ezingama-46 ezingekho mthethweni ze-Erimin-5 ezithinjiweyo zavavanyelwa iimpawu zazo zomzimba nezekhemikhali.Isithako esisebenzayo, i-dopant, i-diluent yokuqala, kunye nedayi zenza iimpawu zeekhemikhali zethebhulethi.Iziphumo zabonisa ukuba i-Nimetazepam yeyona nto ixhaphakileyo esebenzayo kuninzi lweepilisi ezithinjiweyo.Ilactose iye yafunyaniswa njengeyona diluent iphambili kwiisampulu ezininzi, ilandelwa yimannitol kunye nedicalcium phosphate dihydrate.Ukutshona kwelanga okutyheli kufunyenwe kwiisampulu ezininzi zeepilisi, ezisetyenziswa zodwa okanye zidityaniswe nezinye iidayi (umz. itartar kunye neLichenol 4R) ukunika ipilisi umbala wepesika/orenji.Iipilisi eziluhlaza kwisampuli ziqulethe iidayi eziluhlaza okwesibhakabhaka kunye ne-tartar.I-Diazepam isisiyobisi esichasene nokuxhalaba kwaye sisithako esisebenzayo kwipilisi enye kuphela ye-46.I-Nitrazepam, i-sedative enamandla kunye ne-hypnotic kunye neziyobisi zabazali ze-nitrazepam, zifunyenwe zikhompawundi zesibini, kunye ne-caffeine ibe yinto ephambili edibeneyo kwiipilisi ezintathu.

Ngowama-2003, iSingapore yathimba iipilisi zeErimin-5 ezingama-94 200.Ibhubhoratri yeBhodi yeNarcotics yeCentral (CNB) yenza iimvavanyo kwiipilisi kwaye iziphumo ziqinisekisile ukuba ngokwenene ziyi-nitrazepam.