I-Clobetasol propionate inokunyangwa kwi-psoriasis?Zonke izifo zesikhumba eziqhelekileyo?

I-Clobetasol propionateinokunyangwa i-psoriasis.

Izithethantonye:

I-17-propionate; cgp9555; i-Clobetasol 17-isisombululo se-propionate, i-100ppm; i-Cloβsol propionate; i-21-Chloro-9-fluoro-11b, i-17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-dione; I-CLOBETASOL 17-PROPIONATE USP;[(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3 -oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;Dermovate

Ukusetyenziswa:

I-Clobetasol Propionateyipropionate yetyuwa ye-clobetasol, i-topical synthetic corticosteroid ene-anti-inflammatory, anti-pruritic, kunye ne-vasoconstrictive properties.I-Clobetasol propionate yenza umphumo wayo ngokuzibophelela kwi-cytoplasmic glucocorticoid receptors kwaye emva koko isebenze i-glucocorticoid receptor mediated gene expression.Oku kubangela ukuhlanganiswa kweeprotheni ezithile ezichasayo, ngelixa zivimbela ukuhlanganiswa kwabalamli abathile abavuthayo.Ngokukodwa, i-clobetasol propionate ibonakala ibangela i-phospholipase A2 iiprotheni ze-inhibitory, ngaloo ndlela ilawula ukukhutshwa kwe-arachidonic acid evuthayo kwi-membrane phospholipids nge-phospholipase A2.

I-Clobetasol propionate yi-17-O-propionate ester ye-clobetasol kwaye ivela kwi-clobetasol kunye ne-propionic acid.I-corticosteroid enamandla, isetyenziselwa ukunyanga izifo ezahlukeneyo zesikhumba, kuquka i-exzema kunye ne-psoriasis.
I-Clobetasol propionate yayinelungelo elilodwa lomenzi ngo-1968 kwaye yaqala ukusetyenziswa kwezonyango ngo-1978.I-Clobetasol propionate isetyenziselwa ukunyanga izifo ezahlukeneyo zolusu kuquka i-eczema, i-herpes labialis, i-psoriasis, kunye ne-lichen sclerosus.Ikwasetyenziselwa ukunyanga izifo ezininzi ze-auto-immune, kuquka i-alopecia areata, i-lichen planus (i-auto immune skin nodules), kunye ne-mycosis fungoides (T-cell skin lymphoma).Isetyenziswe njengonyango lokuqala lwe-GVHD ebukhali kunye nengapheliyo yesikhumba. I-Clobetasol propionate (i-Cormax, i-Temovate, i-Embeline, i-Olux) yenye yezona zinto zinamandla kwii-agent ezikhoyo ngoku kwaye ibonakaliswe kunyango lwexesha elifutshane lokukrala. okanye ukuphazamiseka kwe-hyperplastic.Yinto eyenziwe nge-fluorinated corticosteroid.Inokubangela impendulo ekhawulezayo okanye ixesha elide kunezinye i-corticosteroids ye-topical.Kunconywa ukuba i-clobetasol ibe nesicelo esiphezulu se-60 g / ngeveki ingekho ngaphezu kweentsuku ezili-14 ngaphandle kokuvalelwa kwaye akufanele isetyenziswe kubantwana abangaphantsi kweminyaka eyi-12.

Isisombululo se-betamethasone i-21-methanesulfonate (4 g) kwi-dimethylformamide (25 ml) iphathwe nge-lithium chloride (4 g) kunye nomxube oshushu kwi-steam bath imizuzu engama-30.Ukungcungcuthekiswa ngamanzi kwanika imveliso ekrwada eyaphinda yadityaniswa ukuze ifikeleleke kwikhompawundi yetayitile, iMP 226°C.
I-Clobetasol idla ngokuguqulelwa kwipropionate njengefomu eluncedo ngokusabela ngepropionic anhydride.