CAS: 38304-91-5 Minoxidil alostil lonolox

Intshayelelo

I-Minoxidil, eyaziwa ngokuba yi-idine yoxinzelelo olude, i-Minoxidil, i-molecular formula kunye nobunzima be-molecular weight C9H15N5O = 209.25, imhlophe okanye i-crystalline powder emhlophe, i-soluble kancinane emanzini okanye i-chloroform, i-soluble kancinane kwi-ethanol, i-soluble kancinane kwi-acetone, i-acetic acid.Inokuthi isebenze ngokuthe ngqo eludongeni lomthambo wegazi, ivule i-arterioles, inciphise ukuxhathisa kwe-peripheral, inciphise uxinzelelo lwegazi, kwaye inyuse izinga lentliziyo kunye nokuphuma kwentliziyo.Nangona kunjalo, umphumo wayo we-antihypertensive ubaluleke kakhulu kwaye uhlala uhleli kune-hydrazine.

Impembelelo ye-Pharmacological

I-Minoxidil yandisa i-arterioles ngokuthe ngqo, ngaloo ndlela inciphisa uxinzelelo lwegazi, kodwa indlela echanekileyo ayaziwa.Le mveliso ayidabuli ii-venules.Ukunciphisa ukuxhatshazwa kwe-vascular peripheral kukhokelela kwisantya sentliziyo ye-reflex esheshayo kunye nokunyuka kwemveliso yenhliziyo.Umsebenzi we-Renin uyanda emva kwe-hypotension, okubangelwa ukugcinwa kwamanzi kunye ne-sodium.Le mveliso ayiphazamisi i-vascular motor Chemicalbook reflex, ngoko ke i-orthostatic hypotension ayinakwenzeka.I-Minoxidil yinto eqhelekileyo esetyenziswayo kunye neyeza elisebenzayo lokunyanga ukulahleka kweenwele, kodwa iziphumo zayo ze-pharmacological kunye neeseli ezijoliswe kuzo azicaci kakuhle.Kwiminyaka yakutshanje, uphando lubonise ukuba iMinoxidil inokukhuthaza ukukhula kweenwele ngezi ndlela zilandelayo.

Iyeza elithathwa ngomlomo elisetyenziswa eklinikhi ukuthoba uxinzelelo lwegazi

I-Minoxidil luhlobo lweyeza lomlomo elisetyenziselwa ukwehlisa uxinzelelo lwegazi ekliniki, eyaziwa ngokuba yi-Changbaridine, i-piperazine enediamine, i-hypotenidine kunye ne-Minlohemoidine.Yeyomsebenzi wokuvula umjelo we-potassium, onokuthi uphumle ngokuthe ngqo i-vascular smooth muscle kwaye ibe nefuthe elinamandla le-artery dilatation, ukunciphisa ukunyanzeliswa kwe-peripheral, i-vascular dilatation kunye noxinzelelo lwegazi, kodwa ayinayo impembelelo kwimithwalo yevolumu, ngoko inokukhuthaza ukubuya kwe-venous.Ngexesha elifanayo, ukuphuma kwentliziyo kunye nesantya senhliziyo kunokunyuswa ngenxa yokulawulwa kwe-reflex kunye nefuthe elihle le-frequency, kodwa ayibangeli i-postural hypotension.Ngokusetyenziswa kweklinikhi kunyango lwe-refractory hypertension kunye ne-renal hypertension.Ingasetyenziselwa uxinzelelo olubi kakhulu kunye nokungaphenduli kakuhle kwamanye amachiza okulwa noxinzelelo, kodwa kufuneka kudityaniswe ne-diuretics ukuphepha amanzi kunye nokugcinwa kwe-sodium.Xa kudityaniswa neziyobisi ze-β-blocking, ukusebenza kwayo kunokunyuswa kwaye kuncitshiswe ukusabela okubi.Esinye isiphumo sokusetyenziswa kwexesha elide leMinoxidil kunye neChemicalbook kukuba iinwele zomzimba zinokunyuka kancinci ngokuqhubeka nokusetyenziswa kwechiza, njengeenwele zengalo.Kodwa ngokubanzi phakathi kwemida eyamkelekileyo.Iziphumo ezimbi kakhulu zokulawulwa komlomo ziquka ukufumana ubunzima kunye ne-edema yomlenze ophantsi obangelwa ngamanzi kunye nokugcinwa kwe-sodium, i-palpitation kunye ne-arrhythmia ebangelwa i-reflex sympathetic nerve excitation, kunye ne-hirsusism.Imiphumo emibi kakhulu yamalungiselelo e-topical yaba kukucaphukisa ulusu, i-erythema, pruritus kunye nezinye iimpendulo ze-dermatitis.Nangona isixa sokufunxa ekulungiseleleni i-topical sincinci kakhulu, asinakunyanzelwa ukuba sinokuba nefuthe kwimeko yezigulane ezinembali yesifo senhliziyo.Izigulana ezinesifo se-cerebrovascular, ukusilela kwentliziyo okungabangelwa luxinzelelo lwegazi, isifo sentliziyo, i-angina pectoris, i-myocardial infarction, i-pericardial effusion, ukungasebenzi kakuhle kwezintso kunye nezinye izifo kufuneka zisetyenziswe ngononophelo, i-minoxidil allergy kunye ne-pheochromocytoma izigulane kufuneka zichaswe.