Human Choroinic Gonadotrophin HCG CAS:9002-61-3

I-chorionic gonadotropin yomntu (hCG) yihomoni ye-glycoprotein ekhutshwa ziiseli ze-placental endodermal.Umsebenzi wayo oyintloko kukukhuthaza i-corpus luteum, ehambelana nokukhupha okuqhubekayo kwe-estrogen kunye ne-progesterone, ukwenzela ukukhuthaza ukubunjwa kwe-uterus ye-decidual kunye nokwenza i-placenta ikhule kwaye ikhule.Ngokukhawuleza ukuba i-embryo ifakwe, iiseli ze-blastoderm ziqala ukukhupha i-hCG, ngoko ukukhulelwa kunokumiselwa ngamanqanaba e-hCG egazini okanye kumchamo.

Yayiqulunqwe ngeentsalela ze-amino acid ezingama-244, ezinobunzima be-molecular 36.7kDa kunye nobukhulu be-7.5 × 3.5 × 3 nm.I-heterodimer ene-subunit efanayo ye-α njenge-luteinizing hormone (LH), i-hormone ye-follicle-stimulating (FSH) kunye ne-thyrotropin (TSH), kodwa i-subunit ehlukeneyo ye-β.I-subunit ye-α iqulethe i-92 i-amino acid eseleyo, kwaye i-β subunit iqulethe i-145 i-amino acid eseleyo.

Ukuhlanganiswa kwe-hCG kwabasetyhini kwanda kakhulu emva kokukhulelwa, kwaye ubukho be-hCG kwi-plasma kunye nomchamo yenye yezibonakaliso zokuqala zokukhulelwa kwaye isetyenziselwa uvavanyo lokukhulelwa.

(1) Inomsebenzi we-FSH kunye ne-LH ukugcina ubude bobomi be-menstrual corpus luteum kunye nokwenza i-menstrual corpus luteum ibe yi-gestational corpus luteum;

(2) Ukukhuthaza i-aromatization ye-androgens kwi-estrogen, kwaye ikhuthaze ukubunjwa kweprogesterone;

(3) Ukuthintela umphumo wokuvuselela i-lectin yesityalo kwi-lymphocytes, i-chorionic gonadotropin yomntu inokubhengezwa kumphezulu weeseli ze-trophoblast, ukuze ugweme ukuhlaselwa kweeseli ze-embryonic trophoblast ngama-lymphocytes oomama;

(4) ukusebenza kwe-LH, ngaphambi kokuba i-pituitary yomntwana ikhuphe i-LH, ivuselela i-testis ye-fetus ukuba ikhuphe i-testosterone ukukhuthaza ukuhlukana ngokwesondo kwamadoda;Inokukhuthaza uphuhliso lwe-gonadal, indoda inokuvuselela amandla eeseli ze-testis mesenchymal, inyuse ukukhutshwa kwehomoni yamadoda (testosterone).Kubaluleke kakhulu kunyango lwezigulane zamadoda ezineziphene ezidibeneyo ze-pituitary, ezingenakukhuthaza kuphela ukuphuhliswa kwe-gonad kunye nokuphuma kwehomoni yesilisa, kodwa nokukhuthaza ukuphuhliswa kweempawu zesini sesibini.

(5) Iyakwazi ukubophelela kwi-TSH ye-receptor yeeseli ze-thyroid kunye nokukhuthaza umsebenzi we-thyroid.