HU-210 CAS NO: 112830-95-2

I-HU-210 yi (--) enantiomer ye-11-OH-D 8-THC-DMH, ephantse ibe nayo yonke imisebenzi ye-cannabinoids, ngelixa (+) enantiomer, ebizwa ngokuba yi-HU-211, ayisebenzi njenge-cannabinoid, kodwa isebenza endaweni ye-cannabinoid njengomchasi we-NMDA oneziphumo ze-neuroprotective.

I-HU-210 inokukhuthaza ukwanda, kodwa kungekhona ukuhlukana, kweeseli ze-embryonic hippocampal neural stem kunye neeseli ze-progenitor ngokuvula i-CB 1 receptor, i-G i / o iprotheni, kunye ne-ERK yokubonisa ngokulandelelana.Oku kukhula kwe-nerve kwanda kubonisa imfuno yokuchasana nokuxhalaba kunye nemiphumo yokudakumba.

Kanye kunye nezinye i-cannabinoids zokwenziwa, ezifana ne-WIN 55,212-2 kunye ne-JWH-133, i-HU-210 ikhusela ukuvuvukala okubangelwa yi-Alzheimer's disease-associated beta amyloid, ngaphezu kokuthintela ukuphazamiseka kwengqondo kunye nokulahlekelwa kwamanqaku e-neuronal.Esi siphumo esichasayo sibangelwa kukusebenza kwee-receptors ze-cannabinoid, ezithintela ukusebenza kweeseli ze-microglia ezivuthayo.Ukongeza, i-cannabinoids yaphelisa ngokupheleleyo i-neurotoxicity ehambelana nokusebenza kweeseli ze-microglial kwiimodeli zeempuku.

I-HU-210 i-painkiller enamandla enemiphumo emininzi efana ne-THC yendalo.

I-LD50 yomlomo ye-HU-210 yi-5,000mg / kg kwiigundane kunye ne-14,200mg / kg kwimivundla.I-LDLO (idosi ephantsi ebulalayo) ye-HU-210 ebantwini yi-143mg / kg.I-LD50 ye-caffeine iqikelelwa ukuba yi-150-200 mg / kg.I-Delta-8-THC LD50 ayizange iqinisekiswe.Kuphononongo lwe-1973, iinkawu kunye nezinja ezinikwe i-9,000 mg / kg ye-Delta-8-THC yayingabulali.