High Purity Pharma API CAS14769-73-4 Hydrochloride Levamisole Base
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Ulwazi olusisiseko
Ingcaciso
I-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole ene-S uqwalaselo.Isetyenziselwa (ngokubanzi njengetyuwa ye-monohydrochloride) ukunyanga usulelo lwe-parasitic worm kwiihagu, iigusha kunye neenkomo kwaye yayifudula isetyenziswa kwi-huma njenge-adjuvant kwi-chemotherapy kunyango lwezomhlaza ezahlukeneyo.Ikwasetyenziswa ngokubanzi njengento yokukrexeza kwi-coccaine.
Iimpawu
I-Levamisole (i-Ergamisol) iyeza elichasayo eliye lafunyanwa ukuba liphucule ukusebenza kwe-T-cell kunye nokukhuseleka kwamaselula.Ichiza liphucula ukusinda kwezigulane ezinomhlaza we-colorectal owenziwe ngokutsha xa zidityaniswa ne-5-fluorouracil;indlela yolu nxibelelwano ayaziwa.I-Levamisole ayinawo umsebenzi we-antitumor ngokuchasene nomhlaza osekiweyo okanye we-metastatic kwaye ayizange ifunyanwe iluncedo kunyango lwe-adjuvant ye-cancer ngaphandle komhlaza we-colorectal.
Iziphumo ezimbi kakhulu ze-levamisole sisicaphucaphu kunye ne-anorexia.Amaqhakuva elusu, ukurhawuzelelwa, iimpawu ezifana nomkhuhlane, nefiva nazo ziye zabonwa.
Iimpawu
I-Levamisole (Ergamisol) yaphuhliswa ekuqaleni njengeyeza elichasayo.Yenza imiphumo evuselelayo yee-antigens, i-mitogens, i-lymphokines, kunye nezinto ze-chemotactic kwi-lymphocytes, i-granulocytes, kunye ne-macrophages.Ibonakaliswe ukuba yonyusa i-T cell-mediated immunity.
I-Levamisole isetyenziswe ngempumelelo ekunyangeni izifo ezingapheliyo.Ikwavunyiwe ukuba isetyenziswe ngokudibeneyo ne-fluorouracil kunyango lomhlaza wesisu.
Ukusetyenziswa
Usebenzisa Isilungisi sempendulo yebhayoloji.
Usebenzisa I-Levamisole isetyenziselwa iimeko zokuqala kunye nesibini ze-immunodeficient, izifo ezizimelayo, izifo ezingapheliyo kunye nezifo eziphindaphindiweyo, i-adenocarcinoma yamathumbu amakhulu, i-helmintosis, kunye ne-rheumatoid arthritis.Izithethantonye zeli chiza yi-decaris, i-tetramizole, kunye nezinye.
I-Levimasole ikwaliyeza elikhethiweyo kwi-acardiasis.Uphando oluninzi lubonisa ukuba idosi enye ye-levamisole iphilisa ukusuka kwi-90 ukuya kwi-100% yezigulane ezine-ascardiasis, ngakumbi ezo zosulelwe yi-A. duodenale.Ayisebenzi kangako kwi-ancylostomiasis kunye ne-strongyloidiasis.Nangona kunjalo, ayisebenzi ngokuchasene ne-N. americanus.Kubonakala ngathi inempembelelo ye-gangliostimulating kwizicubu ze-parasite kuzo zombini imimandla ye-parasympathetic kunye novelwano.Ngaphezu koko, kucingelwa ukuba eli chiza linempembelelo ye-immunomodulatory kwi-host organism.Izithethantonye zeli chiza yi-decaris, i-solacil, i-ergamisol, i-tramisol, i-immunol, kunye nabanye.
Ukusetyenziswa kweKlinikhi
Ascariasis Hookworm usulelo
I-Levamisole isetyenziswe kwi-rheumatoid arthritis kunye nezinye iimeko ezithi ziphendule kumsebenzi wayo wokuzivikela.
Umsebenzi woNyango
I-Antiinflammatory
Umsebenzi we-Antimicrobial
Umsebenzi wayo ophambili uchasene ne-Asc.lumbricoides kunye hookworms.Iintshulube zikhubazekile kwaye ziphuma ilindle kwiiyure nje ezimbalwa.
Ukusetyenziswa kwezamayeza
I-l-isomer ye-tetramisole, ekhoyo njenge-monohydrochloride.I-d-isomere ayinamsebenzi we-anthelmintic.Inyibilika kakhulu emanzini kwaye izinzile kwimeko eyomileyo.
Indlela yokwenza
I-Levamisole inomsebenzi we-immunomodulating.Kukholelwa ukuba ilawula iinkqubo zeselula ze-immune system, kwaye indlela yokusebenza kwayo inokunxulunyaniswa nokusebenza kunye nokukhula okukhulayo kwe-T-lymphocytes, ukwanda kwamanani e-monocytes kunye nokusebenza kwe-macrophages, kunye nokunyuka komsebenzi kunye ne-hemotaxis ye-neutrophylic. iigranulocytes.I-Levamisole ikwabonisa isenzo sokulwa.Kwakhona kwandisa ukumelana nomzimba jikelele kunye nokubuyisela okutshintshileyo kwe-T-lymphocyte kunye nomsebenzi we-phagocyte.Iyakwazi ukuzalisekisa umsebenzi we-immunomodulatory ngokomeleza ukusabela okubuthathaka kwe-immunity yeselula, iyancipha ukuphendula okunamandla, kwaye ingabi nampembelelo kwimpendulo eqhelekileyo.