GW-0742 SARMs Powder |GW610742 CAS 317318-84-6

inkcazelo emfutshane:

GW-0742
Igama leMchiza:[4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid
Izithethantonye:GW610742 okanye GW0742
Inombolo yeCAS :317318-84-6
Ifomula yemichiza:I-C21H17F4NO3S2
Ubunzima beMolekyuli:471.5
Ubunyulu:Hayi ngaphantsi kwe-99.0% (HPLC)
Imbonakalo:Ukuqina kwekristale emhlophe
Indawo enyibilikayo ye-GW0742:134.5- 135.5 °C
Ugcino:Gcina kwiqondo lokushisa, uvalwe ngokuqinileyo, kude nobushushu, ukukhanya kunye nomswakama.
Isicelo:I-SARM entsha efana ne-GW501516

Thumela i-imeyile kuthi

Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukusetyenziswa

Ukukhuluphala, isifo seswekile, i-dyslipidemia kunye nesifo se-cardiovascular Iyeza lokulinga lithetha ukulawula i-lipids kunye nokunyusa izinga le-HDL, okanye i-cholesterol enhle, egazini.I-cell-permeable, ikhompawundi ye-thiazolyl esebenza njengento enamandla, ubudlelwane obuphezulu, i-agonist ye-PPARδ.Ibonisa ukukhetha kwe PPARδ xa kuthelekiswa ne PPARα kunye ne PPARγ.Ayiphumi kuwo nawuphi na umsebenzi ngokuchasene nezinye ii-receptors zenyukliya okanye ezingezizo ezenyukliya.Kuxelwe ukuba yonyusa i-cholesterol efflux kunye ne-ABAC1 ukubonakaliswa kwi-macrophages, fibroblasts, kunye neeseli zamathumbu.

I-Cardarine isetyenziswe ngabadlali abakhuphisanayo kwimidlalo emininzi eyahlukeneyo.Ngokomzekelo, iimbaleki zonyamezelo zinokunyusa ukunyamezela kokuzivocavoca ngokufaka le PPAR kunye ne-AMP ye-analog drug AICAR, okanye iqhube i-cardarine solo.Ngenxa yoko, baya kuba namandla amakhulu okufikelela kwi-RPM ephezulu ngexesha lokugijima kwabo ngaphandle kokubetha isantya sentliziyo esiphezulu.Oku kuya kuvumela imbaleki/umkhweli webhayisikile/indadi ukuba ikhohlise izinga layo eliphezulu lentliziyo kwaye ihambe ixesha elide ngaphandle kokubethwa ngumoya, isenza esi sitaki sibe sisixhobo esimangalisayo sokusetyenziswa kwimidlalo yokunyamezela.Ngokwenyani, kumava obuqu ndiyakwazi ukuxelela ukuba i-cardarine inokunkqonkqoza ngaphezulu kwemizuzwana ye-30-45 ukusuka kwixesha le-5K ukuba isetyenziselwa ukukhokelela kugqatso.

Inkcazo

AMAZWI ENGUNDOQO: Ukulahlekelwa ngamafutha, ukuphucula unyamezelo, akukho siphumo sisecaleni, umakhi womzimba, ukunyanga ukutyeba kakhulu kunye nokunceda ukugcina ubunzima, kwandisa ubunzima bezihlunu.

I-Cardarine (GW-501516) idityaniswe kwicandelo le-SARMS, nangona kunjalo kwisakhiwo kunye nenkcazo, yi-modulator ye-PPAR.Njengemodyuli ye-PPAR, yenza i-protein kinase isebenze i-AMP kwaye ivuselele ukunyuswa kwe-glucose kwi-tissue ye-skeletal muscle.I-GW-501516 inamandla okubuyisela umva iingxaki zemetabolism ngokuvuselela i-fatty acid oxidation.Kuthathwa njengonyango olunamandla lokutyeba kunye nezinye iimeko ezinxulumene noko.

I-GW501516 ligama lechiza le-Glaxo Wellcome (i-GW imele inkampani kwaye inani lelo lemveliso).Ikwabizwa ngokuba yi-GW-501,516, GW1516, GSK-516).Yi-PPARδ receptor agonist engazange ithathwe ngakumbi kunezilingo zeklinikhi.Ngokunjalo uvaliwe kwezemidlalo.Ingena kwiindawo ezininzi kuluhlu, kubandakanywa ngokukodwa njenge "peroxisome Proliferator Activated Receptor δ (PPARδ) agonists (umz. GW501516)".Kodwa iya kuba phantsi kwecandelo elitsha lokubambisa le-WADA lazo zonke “izinto ezingavunywanga” ezijolise ekuyekiseni nasiphi na isiyobisi esingavumelekanga esisetyenziswa ngabadlali.

I-GW501516 (ekwaziwa ngokuba yi-GW-501,516, GW1516, GSK-516) yi-PPAR & receptor agonist eyaqanjwa ngentsebenziswano phakathi kweLigand Pharmaceuticals kunye neGlaxoSmithKline ngeminyaka yoo-1990, yangeniswa kuphuhliso lwezonyango njengomgqatswa weziyobisi kwizifo ze-metabolic kunye ne-cardiovascular disease. , kwaye yashiywa kwi-2007 ngenxa yokuba uvavanyo lwezilwanyana lubonise ukuba iyeza labangela ukuba umhlaza uphuhle ngokukhawuleza kwizitho ezininzi.

Kuphando lwe-2007 lwapapashwa lubonisa ukuba amanani aphezulu e-GW501516 anikwe iigundane aphucula kakhulu ukusebenza kwawo ngokomzimba;umsebenzi waxoxwa ngokubanzi kumajelo eendaba adumileyo, kwaye kukhokelele kwimarike emnyama yomgqatswa weziyobisi kunye nokuxhatshazwa kwayo ngabadlali njengearhente yedoping.

Usetyenziso

I-GW501516 ingasetyenziswa ngabadlali njengeyeza lokuphucula ukusebenza kwe-ergogenic engazange ilawulwe ngoku yimimiselo okanye ifunyenwe ngovavanyo oluqhelekileyo.Omnye wabaphandi abaphambili kuphononongo malunga nonyamezelo oluphuculweyo waphuhlisa uvavanyo lomchamo ukubona ichiza, kwaye walenza ukuba lifumaneke kwiKomiti yeOlimpiki yaMazwe ngaMazwe.

I-GW ivuselela ukufunyanwa kwe-glucose kunye nezicubu zomzimba zamathambo.Itshisa amanqatha ngokuvuselela i-fatty acid oxidation.Kucetyiswa njengonyango olunokubakho lokutyeba ngenxa yokukwazi ukunyibilikisa amanqatha ngokukhawuleza.Kwakhona, kuthiwa i-Cardarine inyusa i-HDL ngomlinganiselo we-79% (i-cholesterol enhle) kwaye iyancipha i-LDL (i-cholesterol embi) kwizilingo zeSigaba II zangoku.I-GW 501516 yi-agonist ye-PPARδ.Oku kunceda ukunyusa amanqanaba akho e-HDL ukusuka kwinkcazo ephuculweyo yesithuthi se-cholesterol ABCA1.