I-Chemical Material Anesthetics amayeza ancedisayo CAS 59-46-1 PROCAINE
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Ulwazi olusisiseko
Inkcazo
Iprocaine sisithomalalisi sendawo esinepara-amino.Uvakalelo lubandakanya ikakhulu ubugqirha, amazinyo kunye nobugcisa bezilwanyana.
Iipropati zeMichiza
Ityuwa ye-hydrochloride ye-2-(diethylamino) ethyl p-aminobenzoate (C13H21ClN2O2 okanye i-N2C6H4COOCH2CH2NH(C2H5)2HCl) ngokuqhelekileyo ibizwa ngokuba yi-procaine.Nangona i-PABA ester inganyibiliki emanzini, ityuwa ye-hydrochloride inyibilika kakhulu emanzini.
Usebenzisa
I-1.Procaine (i-Novocain) isetyenziswa kakhulu kwiinkqubo zamazinyo okanye zonyango ezifuna i-anesthesia yokungena, i-peripheral block, okanye i-spinal block.
I-2.inhibitor ye-sodium channel
3. Iprocaine i-block block ye-sodium kunye ne-inhibitor yeenkqubo ezahlukeneyo.
Ukusetyenziswa
Ukusetyenziswa kweKlinikhiIprocaine ikhawuleza kakhulu imetaboliseni kwiplasma ngecholinesterases nakwisibindi nge-ester hydrolysis ngepseudocholinesterase.Ubomi besiqingatha se-in vitroelimination bumalunga nemizuzwana engama-60.Nayiphi na imeko enciphisa ugxininiso lwe-cholinesterase inokunyusa ukuvezwa kwiprocaine kunye netyhefu enokubakho.Ukuncipha komsebenzi we-enzyme kunokufunyanwa ngokusilela kwemfuza, isifo sesibindi, isifo esibi, ukungondleki, ukusilela kwezintso, ukutshisa, i-thirdtrimester yokukhulelwa, kunye nokulandela utyando lwe-cardiopulmonary bypasssurgery.I-Ester hydrolysis ivelisa i-PABA, i-compounds enoxanduva lokwaliwa okuxhaphakileyo kwi-ester anesthetics.Iprocaine ayisetyenziswanga ngokwesihloko ngenxa yokungakwazi ukudlula kwi-lipid membranes kwaye ifumana ukusetyenziswa njenge-aninfiltration agent ye-cutaneous okanye i-mucous membranes, iinkqubo ezimfutshane.Iprocaine ikwasetyenziselwa i-peripheral nerveblock kunye ne-epidural agent ukuxilonga ii-syndromes zentlungu.