I-CAS: 152685-85-3 HEMORPHIN-7 TYR-PRO-TRP-THR-GLN-ARG-PHE HEMORPHIN-7

I-LVV-hemorphin-7 (LVV-h7) yi-peptide ye-bioactive ebangelwa ukuthotywa kwe-hemoglobin ye-β-globin chain.I-LVV-h7 i-agonist ethile ye-angiotensin IV receptor.Le receptor ingokweklasi ye-insulin-regulated aminopeptidase (IRAP) kwaye inomsebenzi we-oxytocin.Apha, sijonge ukuvavanya: i) ingaba i-LVV-h7 iguqula ukuziphatha kwezicubu ezigxininisiweyo kunye nempendulo ye-cardiovascular kuxinzelelo, kwaye ii) indlela engaphantsi kwemiphumo ye-LVV-h7 ibandakanya ukusebenza kwe-oxytocin (OT) receptor, enokuba isiphumo sokuncitshiswa komsebenzi we-IRAP weproteolytic ngexesha elongezelelweyo.Iigundane zeWistar eziyindoda endala (270 -- 370 g) zifunyenwe (ip) LVV-h7 (153 nmol/kg) okanye umthwali (0.1 ml).Iiprothokholi ezahlukeneyo zasetyenziswa: i) Uvavanyo lwe-Open Field (OP) lwemidlalo / imisebenzi yokuhlola;ii) Elevated Cross mazes (EPMs) zokuziphatha okufana nexhala;iii) Uvavanyo lokuqubha olunyanzelwayo (FST) lovavanyo lokuziphatha okunjengokudakumba kunye ne-iv) inaliti yomoya yokusabela kwi-cardiovascular reaction to acute stress exposure.I-Diazepam (2 mg / kg) kunye ne-imipramine (15 mg / kg) zisetyenziswe njengolawulo oluhle lwe-EPM kunye ne-FST, ngokulandelanayo.I-OTr receptor (OTr) abachasi be-atosiban (i-1 kunye ne-0.1 mg / kg) yayisetyenziselwa ukumisela ukubandakanyeka kwendlela ye-oxytocin.Sifumene ukuba i-LVV-h7: i) yandisa inani lokungeniswa kunye nexesha elichithwe kwi-maze ngeengalo ezivulekileyo, ezibonisa ukuchasana nokuxhalaba;ii) Ukuvuselela iziphumo zokuthomalalisa uxinzelelo kwiimvavanyo zeFS;iii) Ukwanda kokuphonononga kunye nokuhamba;iv) ayizange iguqule iimpendulo ze-cardiovascular and neuroendocrine kuxinzelelo olunzima.Ukongeza, ukunyuka komthambo kunye ne-LVV-h7 yempembelelo ye-antidepressant eyenziwe yabuyiselwa yi-OTr antagonists.Siphetha ukuba i-LVV-h7 imodareyitha ukuziphatha okuboniswe ngokuyinxalenye yi-oxytocin receptor.