Trenbolone Cyclohexylmethylcarbonate CAS:23454-33-3 11-trien-3-one carbonate cyclohexylMethylcarbonate (8CI)

Brief introduction:
Trenbolone (TRE) is a widely used steroid protein assimilation hormone. It is a chemosynthetic derivative similar to the human male hormone testosterone in structure and activity. It can promote protein synthesis, increase appetite, increase muscle, promote calcium and phosphorus in bone tissue, and can be used clinically to treat severe nutritional deficiencies and osteoporosis, but it is also the most frequently used type of sports stimulant. Group bolone cyclohexyl methyl carbonate can be used as a synthetic intermediate of group Bolone.
Preparation:
Group bromcyclohexyl methyl carbonate is prepared as follows:
3G17/3-hydroxy-estradiol-4,9, 11-triene-3-one was dissolved in pyridine at 15℃ and 0℃ under agitation and nitrogen atmosphere. Keep the temperature between 0 and 10 degrees Celsius. Slowly add 50ml hexahydrobenzyl chloride Chemicalbook formate, then warm the whole mixture to ambient temperature, stir for 2 hours, then cool to 0 ° C. Add the triethylamine and stir for 30 minutes to raise the temperature to ambient and pour the reaction mixture into the water/ice mixture. It was extracted with methylene chloride, and the organic phase was washed with water to neutral, dried with sodium sulfate, and evaporated under vacuum until dry. The residue was separated by chromatography on silica gel, eluted with 4:1 mixture of benzene/ethyl acetate, and recrystallized from isopropyl ether/hexane mixture. Chromatography was performed again on silica gel, eluted with a mixture of benzene/ethyl acetate, and finally recrystallized from cyclohexane and petroleum ether to obtain 1.60g group bromcyclohexyl methyl carbonate. The product appears as a prism soluble in ethanol, ether, benzene, acetone, and chloroform, but insoluble in water, dilute acid, and lye solutions.