Teduglutide CAS:197922-42-2 Teduglutide(ALX-0600) Revestive

Function:
Teduglutide, known in English as Teduglutide, is an analogue of glucagon-like peptide 2 (GLP-2), a naturally occurring hormone that reduces gastric emptying and secretion and regulates the growth, proliferation, and repair of cells in the intestinal lining. The drug increases the number of these cells, which increase absorption in the small intestine and reduce diarrhea.
Preparation:
The formation of five-membered ring structure is significantly related to the right amino acid of Asp or Asn, and Gly is the most easily formed ring structure when Gly is coupled before Asp due to the lack of protective group and low steric hindrance in the side chain. Therefore, it is inevitable that the sequence coupling method will make the N-terminal amino acids of Tedulu Chemicalbook peptide form a five-membered ring in the process of synthesis, which will reduce the purity. Therefore, in order to solve the degradation problem of the Asp-Gly fragment, a fully protected fragment with the structure shown in SEQIDNO:2 was first synthesized by fragment coupling. The fully protected fragment was the first ~ fourth amino acid of the N-terminal of tidulutide, including the Asp-Gly structure, and then the fully protected fragment was purified. The purified fully protected fragment was solid-phase coupled with the fragment peptide resin with the structure shown in SEQIDNO:12, and the final cleavage was conducted to obtain tidurotide.