Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine
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Tšebeliso
Tšebeliso ea bongaka
Toluene thiazide hangata e sebelisoa e le sedative, se khathollang mesifa le analgesic.Hangata e sebelisoa ho phekola tetanase.Xylazine e tšoana haholo le lithethefatsi tse kang phenothiazine, tricyclic antidepressants le clonidine.E le sethethefatsi, hangata se sebelisoa hammoho le ketamine.Xylazine e bonahala e fokotsa kutloisiso ea 'mele ho insulin le ho kenngoa ha tsoekere.Yohimbine ke mohanyetsi oa alpha2 adrenergic receptor e 'nileng ea sebelisoa ho fokotsa maemo a tsoekere ho ea maemong a phetseng hantle.Yohimbine e khutlisa litlamorao tsa toluene thiazide maemong a kliniki haeba e tsamaisoa ka methapo nakoana kamora hore toluene thiazide e laeloe.
pharmacodynamics
Xylazine ke alpha 2 adrenergic agonist e matla.Toluene thiazide le li-agonists tse ling tsa alpha2 adrenergic receptor li tsamaisoa ho pholletsa le 'mele nakong ea metsotso e 30-40 ha li fanoa.Ka lebaka la lipophilicity ea eona e phahameng, toluene thiazide e susumetsa ka ho toba li-receptor tsa α2 tse bohareng hammoho le li-pharipheral αadrenergic receptors ka har'a lisele tse fapaneng.Joaloka agonist, toluene thiazide e fella ka phokotso ea phetisetso ea methapo ea kutlo ea norepinephrine le dopamine tsamaisong ea methapo e bohareng.E etsa joalo ka ho etsisa ho tlama ha norepinephrine ho li-autoreceptor tse holim'a presynaptic, e leng se fellang ka ho thibela maikutlo a norepinephrine.
Xylazine e boetse e sebetsa e le inhibitor ea lipalangoang ka ho thibela mosebetsi oa lipalangoang oa norepinephrine ka tlhōlisano e thibelang lipalangoang tsa substrate.Kahoo, toluene thiazide e eketsehile haholo K m mme ha ea ka ea ama V max.Sena se ka etsahala ka tšebelisano e tobileng le libaka tse kopanang le libaka tse tlamang tse thibelang ho imeloa kelellong.Ka mohlala, toluene thiazide le clonidine li thibela ho kenngoa ha MIBG (analogue ea norepinephrine) ke lisele tsa neuroblastoma.Xylazine e na le likamano tse fapaneng bakeng sa cholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, le li-receptor tsa opioid.Sebopeho sa eona sa lik'hemik'hale se tšoana haholo le sa phenothiazines, tricyclic antidepressants le clonidine