Tianeptine Sodium CAS: 30123-17-2 5-dioxide Stablon S-Dioxide Sodium Letsoai

SEBELISA

Letsoai la sodium ea Tianeptine ke tricyclic e thibelang ho imeloa kelellong, 'me mokhoa oa eona oa ho imeloa kelellong o fapane le li-antidepressants tse tloaelehileng tsa tricyclic.E ka eketsa ho tsosolosoa ha 5-HT sebakeng sa synaptic, 'me e ka ba le phello ea ho ntlafatsa ho tsamaisoa ha 5-HT neurons.Ha ho na kamano bakeng sa li-receptor tsa choline kapa adrenaline.Matla a antidepressant a tšoana le tricyclic, empa mamello e molemo ho feta tricyclic.Litekong tsa liphoofolo, e ka eketsa ts'ebetso e ikhethileng ea lisele tsa pyramidal ho hippocampus mme ea potlakisa ho hlaphoheloa ha bona kamora ho thibela ts'ebetso.Chemicalbook e ekelitse ho khutlisetsoa ha serotonin ke li-neurone ka har'a cerebral cortex le hippocampus.Ho monya ha tineptine sodium ka har'a tšilo ea lijo ho potlakile ebile ho felile.Kabo e potlakileng, PPB ho fihla ho 94%.E ne e sebelisoa ka ho feletseng ka sebete ka β-oxidation le N-demethylation, 'me ho tlosoa ha terminal T1 / 2 e ne e le khutšoanyane ho 2.5h.Palo e nyane haholo ea moriana (8%) e ile ea ntšoa liphio, haholo-holo metabolites ea eona ho tsoa morotong.Bakuli ba nang le bothata ba renal ba sa sebetseng hantle ba hlakotse T1/2 bakeng sa 1h e atolositsoeng.