Tesamorelin CAS:804475-66-9 Unii-mqg94m5eeo Th 9507
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Tšebeliso
Tesamorelin (INN) (lebitso la khoebo Egrifta SV) ke mofuta oa maiketsetso oa hormone ea ho hōla e lokollang hormone (GHRH) bakeng sa phekolo ea lipodystrophy e amanang le HIV 'me e ile ea amoheloa qalong ka 2010. E hlahisoa le ho ntlafatsoa ke Theratechnologies, Inc. Canada.Setlhare ke peptide ea maiketsetso e entsoeng ka li-amino acid tse 44 tsa GHRH ea motho ka kenyelletso ea sehlopha sa trans-3-hexenoic acid.
Mokhoa oa ts'ebetso
Tesamorelin ke N-terminus e fetotsoeng motsoako o thehiloeng ho 44 amino acid tatellano ea GHRH ea motho.Sebopeho sena sa maiketsetso se fetotsoeng se sebetsa hantle ebile se tsitsitse ho feta li-peptide tsa tlhaho.E boetse e hanana le ho petsoha ka dipeptide aminopeptidase ho feta GHRH ea motho.E susumetsa tlhahiso ea GH e sa feleng le ho lokolla le ho eketsa maemo a insulin-like growth factor (IGF-1).GH e lokollotsoeng e tlama ho li-receptor tse teng lithong tse fapaneng tsa 'mele mme e laola sebopeho sa' mele.Taolo ena e bakoa haholo ke ho kopana ha anabolic le mekhoa ea lipolysis.Leha ho le joalo, mokhoa o ka sehloohong oo tesamoline e fumanoeng ho fokotsa boima ba 'mele oa mafura ke ho fokotseha ha maemo a triglyceride ka mor'a lipolysis.