SARM SR9011 Pharmaceutical Raw Powder For Boosting Exercise Endurance CAS 1379686-30-2
Lintlha tse potlakileng tsa SR9011
Cas No 1379686-29-9
Mantsoe a tšoanang 3-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-
1-carboxamide
Setšoantšo sa C23H31ClN4O3S
Boima ba molucelar 479.03524
SR9011Tlhaloso
SR9011 ke monoma ea methacrylate e sebetsang ka makhetlo a mararo e fanang ka mamaretso a ikhethang ho tšepe.
substrates.
SR9011 e khothaletsoa hore e sebelisoe litlolong tse phekotsoeng tsa peroxide, li-sealants, le li-plastisols tse thehiloeng ho PVC.
Maemo a tšebeliso a 5% ho isa ho 10% ka boima ba 'mele a khothaletsoa.
SR9011 ke REV-ERB e matla le e ikhethang ea maiketsetso.E boetse e na le ts'ebeliso e ntle ea plasma ea vivo / bokong.
Li-nuclear receptors REV-ERB-α le REV-ERB-β li bapala karolo ea bohlokoa ho laola polelo.
ea liprotheine tsa mantlha tsa oache, morethetho oa ho khanna ts'ebetsong le metabolism.Tsamaiso ea SR9011 liphetoho
boits'oaro ba circadian le mokhoa oa circadian oa polelo ea mantlha ea li-clock ho hypothalami ea litoeba.
Polelo ea circadian ea mefuta e mengata ea liphatsa tsa lefutso sebeteng, mesifa ea masapo le
lisele tsa adipose le tsona li ile tsa fetoloa, e leng se ileng sa fella ka ho eketseha ha tšebeliso ea matla.Kalafo ea lijo tse bakoang ke lijo
litoeba tse nonneng tse nang le SR9011 li fokolitse botenya ka ho fokotsa boima ba mafura le ho ntlafatsa dyslipidaemia le hyperglycemia haholo.Liphetho tsena li bontša hore li-ligand tsa maiketsetso tsa REV-ERB tse shebaneng le pharmacologically
morethetho oa circadian o ka ba molemo kalafong ea mathata a ho robala hammoho le mafu a metabolism.
Mokhoa oa ho sebelisa SR9011?
In vitro: SR9011 e ne e sebelisoa ho 5-10 μM concentration in vitro le litekong tsa cellular.
In vivo: Tsamaiso ea IP ea SR9011 e ne e sebelisoa ho 100 mg / kg hang kapa habeli ka letsatsi bakeng sa 12-30.
matsatsi ka mefuta e fapaneng ea litoeba.
Synthesis ea SR9009 le SR9011
| Ntho | Tlhaloso | Sephetho |
| Ponahalo | Phofo e se nang monko, e batlang e le tšoeu kapa e tšoeu | fetisa |
| Identificaton | Nako ea ho boloka tlhōrō e kholo ke netefatsa ho RS | fetisa |
| Tahlehelo ka ho Omisa | Ha e fete 0.5% | 0.33% |
| Assay(HPLC) | E seng ka tlase ho 99.0% | 99.59% |
| Masala a ho besa | Ha e fete 0.1% | fetisa |
| Tšepe e boima | Ha e fete 20 ppm | fetisa |
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