Nociceptin CAS: 170713-75-4 FGGFTGARKSARKLANQ ORL1 PEPTIDE

Nonoreceptor/orphenkephalin FQ (N/OFQ) ke 17-amino acid neuropeptide eo e leng endogenous ligand ea nonoreceptor (ORL-1).Nociceptive peptide, e le sethethefatsi se sebetsang sa antianalgesic, se ka thibela ka katleho phello ea li-painkillers.Tšebeliso ea eona e 'nile ea amahanngoa le mesebetsi ea boko e kang maikutlo a bohloko le thuto ea tšabo.

Khoutu ea lefutso bakeng sa prepronociceptin e fumaneha ho motho Ch8p21.Li-peptide tse utloang bohloko li tsoa ho liprotheine tsa peptide tsa propain, hammoho le li-peptide tse ling tse peli, nocistatin le NocII, tseo ka bobeli li thibelang tšebetso ea li-receptor tsa N/OFQ.Nociceptin e ne e le mohlala oa pele oa reverse pharmacology;Mokelikeli oa NOP o ile oa sibolloa pele ho sibolloa ha li-ligands tsa endogenous ke lihlopha tse peli tse fapaneng ka 1995.

Lithutong tsa liphoofolo, tsela ea receptor ea N/OFQ-NOP le eona e fumanoe e bapala likarolo tse ntle le tse mpe thutong le mohopolong.Ka mohlala, ho senyeha ha tsela ena ho 'nile ha amahanngoa le liphetoho tsa thuto ea tšabo mathateng a boko a kang post-traumatic stress disorder (PTSD).Kahoo, litsela tsa li-receptor li boloka likarabo tsa homeostasis ho tšabo le maemo a sithabetsang.Nociceptor e ka boela ea phetha karolo ea ho thibela mosebetsi oa ho hopola, kaha liphuputso tse ling li bontšitse hore li senya thuto ea sebaka ka vivo ha li ntse li thibela ntlafatso ea nako e telele le phetisetso ea synaptic in vitro.