Taba ea ho thibela botsofali e se e tumme le ho feta lilemong tsa morao tjena, 'me lithuto tse fapaneng li hlaha ka ho sa feleng.
Nako le nako, sehlopha se seng sa lipatlisiso se sibolla ntho e thibelang botsofali e ka re thusang ho phela lilemo tse lekholo.
Rōna batho re na le moeli oa bophelo oa lilemo tse 150, hobane li-telomere li khutsufatsa hanyenyane lilemo tse ling le tse ling tse peli ho isa ho tse tharo, ’me lisele li ka arohana ka makhetlo a ka bang 50, ho bolela Hafrick oa telomere Theory.
Hape ho na le litsebi tse nang le tšepo li re: motho oa pele ea phelang ho fihlela lilemo tse 1000, o hlahile lefatšeng la rona, e ka 'na eaba ke uena.
Ka nts'etsopele ea biomolecular biology, ka letsatsi le leng re ka fumana ntho ea boselamose e tla re thusa ho phela nako e telele.
Kahoo, phela bophelo bo botle, sebetsa ka thata ho etsa chelete, 'me u emele hore theknoloji e hōlile ka letsatsi le leng, mohlomong, u ka phela nako e telele.
Kajeno, ke tlil'o u tsebisa tse ling tsa litlhare tse thibelang botsofali tse tsebahalang haholo, 'me u shebe tse seng kae tseo u li boneng.
1. Epitalon
Epitalon ke peptide ea maiketsetso e thibelang botsofali, e hlahisoang ke ketane ea amino acid alanine-glutamine-asparagine-glycine, e phahamisang ts'ebetso ea telomerase 'meleng ho thusa ho fokotsa sekhahla sa botsofali.
Li-telomere li tšoana le likatiba tse thata tse sireletsang DNA.Li-chromosome tse ngata 'meleng li na le li-telomere lipheletsong ka bobeli;Mosebetsi o ka sehloohong oa telomerase ke ho thusa ho boloka bolelele ba li-telomere 'meleng.
Mafu a mang a amahanngoa le li-telomere tse khutšoanyane, tse lebisang ho tsofalang ka potlako;Epitalon e ka sebelisoa ho phekola mafu a bakang botsofali pele ho nako, joalo ka Bloom syndrome le Werner syndrome.
Epitalon e boetse e thusa ho fokotsa kotsi ea mafu a amanang le khaello ea telomerase, joalo ka lefu la tsoekere, hobane tlhahiso ea insulin e sitisoa ke khaello ea telomerase.
Peptide e ka boela ea e-ba le phello e ntle bophelong ba pelo 'me e ka thusa ho thibela lefu la pelo;Bo-rasaense ba ntse ba ithuta bokhoni ba eona ba ho phekola lihlahala.
2: Curcumin
Turmeric ke motsoako oa lijo tsa Maindia haholo, 'me curcumin ke motsoako o sebetsang ka ho fetisisa o ithutoang ka turmeric, e nang le thepa e matla e khahlanong le ho ruruha le ea antioxidant.
Liphuputso li bontšitse hore curcumin e kenya tšebetsong li-sirtuins (deacetylases) le AMPK(AMP-activated protein kinase), tse thusang ho liehisa botsofali ba lisele le ho lelefatsa bophelo.
Ho phaella moo, curcumin e bontšitsoe ho loantša tšenyo ea lisele le ho atolosa haholo nako ea bophelo ea lintsintsi tsa litholoana, li-roundworms le litoeba;E ka boela ea liehisa ho qala ha mafu a amanang le lilemo le ho fokotsa matšoao a mafu a amanang le lilemo
3: cannabinoid
Metsoako e sebetsang ea cannabis, e tsejoang ka kakaretso e le cannabinoids, ke sehlopha sa metsoako ea terpenoid phenolic, e tsebahalang haholo ho eona ke tetrahydrocannabinol (THC) le cannabidiol (CBD).
CBD e ka loantša li-radicals tsa mahala liseleng tsa letlalo, e sebetsa joalo ka antioxidant le anti-botsofali.Hangata e kenngoa lihlahisoa tsa tlhokomelo ea letlalo 'me hangata e sebelisoa ho kokobetsa bohloko bo sa foleng, ka liphello tse kholo
4: spermidine
Spermidine ke karolo ea tlhaho ea peō ea botona, 'me' mele ea rona (e motona le e tšehali) e hlahisa hoo e ka bang karolo ea boraro ea eona, 'me e meng e tsoa lijong tsa rona.
Mehloli ea eona ea lijo e kenyelletsa: chisi ea khale, li-mushroom, natto, pepere e tala, kokoana ea koro, cauliflower, broccoli, joalo-joalo.
Batho ba Asia ba na le maemo a holimo a arginous acid lijong tsa bona, tse ka amanang le bophelo ba bona bo bolelele.
Lipatlisiso ka spermidine li ntse li eketseha lilemong tsa morao tjena, 'me ho fumanoe hore li na le liphello tse latelang:
Eketsa bophelo ba bophelo bo botle;
Ntlafatsa boemo ba kelello ba maqheku;
Tšusumetso ea neuroprotective;
Ho fokotsa ho shoa ha lisosa tsohle;
Khatello e tlase ea mali;
Hlohlelletsa autophagy le ho lieha senescence;
E etsa hore moriri o hōle ka potlako le ho matlafatsa manala.
5: 'mele oa ketone
E 'ngoe ea mabaka a ka sehloohong a ho ja lijo tsa ketogenic ke ho theola boima ba' mele le ho hlaka kelellong.
Ha 'mele o qala ho chesa mafura a' mele, o hlahisa 'mele ea ketone, e fanang ka matla a hloekileng bokong le ho ntlafatsa ts'ebetso ea eona.
Li-ketones li na le lintho tse thibelang botsofali, 'me liphuputso li fumane hore BHB (beta-hydroxybutyric acid) e ka khothalletsa ho arohana ha lisele, ho thibela botsofali ba lisele, le ho boloka methapo ea mali le boko bo sa le monyenyane.
'Mele o ka hlahisa' mele oa keto ka ho qoba lik'habohaedreite, kapa o ka nka li-supplement tsa exogenous keto ho potlakisa ts'ebetso le ho fokotsa bohloko ba phetoho, e tsejoang e le "keto flu".
Lijo tsa Ketogenic, kapa li-supplement tsa keto tse sa tloaelehang, li ka liehisa botsofali, tsa ntlafatsa ts'ebetso ea kelello, le ho thusa ho thibela mafu a neurodegenerative joalo ka Alzheimer's.
6: Dasatinib
Ha re ntse re tsofala, lisele tse ling tsa rona li qoba sesole sa 'mele.Lisele tsena “tse ntseng li phela” ha li etse seo li neng li lokela ho se etsa, empa li ntse li chesa matla.
Lisele tse joalo tsa "lijo tsohle le ho se sebetse", tse tsejoang hape e le "lisele tsa zombie", kapa lisele tsa senescent, li bokellana ha nako e ntse e ea, li etsa hore 'mele o sebetse hantle.
Ho itima lijo, boikoetliso le mekhoa e meng ea bophelo bo botle e baka autophagy, e hloekisang lisele tsa zombie.
Dasatinib, sethethefatsi sa chemotherapy se sebelisoang ho phekola kankere ea mali, se ka boela sa tlosa lisele tsa mafura tse tsofetseng ka katleho le ho fokotsa ho ntšoa ha li-cytokine tse pro-inflammatory thishung ea adipose ea 'mele.
Ke sethethefatsi sa pele sa Senolytics se fumanoeng, sethethefatsi se khethang ho hloekisa lisele tsa senescent ka ho kena-kenana le litsela tsa pontšo ea lisele tsa senescent, ho thibela ka nakoana SCaps (li-anti-apoptotic pathways).
Lintho tse ka tlosang lisele tsa senescent li kenyelletsa PCC1 ho tsoa ho Chinese Academy of Sciences, hammoho le metsoako e meng e kang quercetin.
Nako ea poso: Feb-24-2023