Selelekela
Minoxidil, e tsejoang hape e le idine ea khatello e telele, Minoxidil, foromo ea limolek'hule le boima ba molek'hule C9H15N5O = 209.25, ke phofo e tšoeu kapa e tšoeu ea crystalline, e qhibilihang hanyenyane metsing kapa chloroform, e qhibiliha hanyenyane ka ethanol, e qhibiliha hanyenyane ka acetone, e qhibiliha ka acetic acid.E ka sebetsa ka kotloloho leboteng la methapo ea mali, ea atolosa li-arterioles, ea fokotsa khanyetso ea peripheral, ea fokotsa khatello ea mali, ea eketsa lebelo la pelo le phallo ea pelo.Leha ho le joalo, phello ea eona ea antihypertensive e bohlokoa haholo ebile e tšoarella ho feta hydrazine.
Pharmacological effect
Minoxidil e fokotsa li-arterioles ka ho toba, kahoo e fokotsa khatello ea mali, empa mokhoa o nepahetseng ha o tsejoe.Sehlahisoa sena ha se atolose li-venule.Ho fokotseha ha peripheral vascular resistance ho lebisa ho lebelo la pelo ea reflex ka potlako le ho eketseha ha pelo.Ts'ebetso ea Renin e eketseha kamora hypotension, e bakang ho boloka metsi le sodium.Sehlahisoa sena ha se kena-kenane le vascular motor Chemicalbook reflex, kahoo hypotension ea orthostatic ha e hlahe.Minoxidil ke lithethefatsi tse sebelisoang ka tloaelo le tse sebetsang bakeng sa phekolo ea ho lahleheloa ke moriri, empa liphello tsa eona tsa meriana le lisele tse lebisitsoeng ha li hlake haholo.Lilemong tsa morao tjena, liphuputso li bontšitse hore Minoxidil e ka khothalletsa kholo ea moriri ka litsela tse latelang.
Sethethefatsi se nooang se sebelisoang tleliniking ho theola khatello ea mali
Minoxidil ke mofuta oa moriana oa molomo o sebelisetsoang ho theola khatello ea mali tleliniking, e tsejoang hape e le Changbaridine, piperazine enediamine, hypotenidine le Minlohemoidine.Ke ea moemeli oa ho bula mocha oa potassium, o ka phomotsang mesifa e boreleli ea vascular ka ho toba 'me o na le phello e matla ea ho fokotseha ha methapo ea mali, ho fokotsa ho hanyetsa ha peripheral, vascular dilatation le khatello ea mali, empa ha e na phello ho lijana tsa molumo, kahoo e ka khothalletsa ho khutla ha venous.Ka nako e ts'oanang, tlhahiso ea pelo le lebelo la pelo li ka eketseha ka lebaka la taolo ea reflex le phello e ntle ea maqhubu, empa ha e bake hypotension ea postural.Clinically sebelisoa a ho phekola refractory kgatelelo ya madi le renal kgatelelo ya madi.E ka boela ea sebelisoa bakeng sa khatello ea mali e matla ka karabelo e mpe ho lithethefatsi tse ling tsa antihypertensive, empa e hloka ho kopanngoa le li-diuretics ho qoba ho boloka metsi le sodium.Ha e kopantsoe le lithethefatsi tsa β-blocking, ts'ebetso ea eona e ka eketseha mme litlamorao tse mpe tsa fokotseha.E 'ngoe ea litla-morao tsa tšebeliso ea nako e telele ea Minoxidil le Chemicalbook ke hore moriri oa' mele o ka eketseha hanyenyane ka tšebeliso e tsoelang pele ea lithethefatsi, joalo ka moriri oa letsoho.Empa ka kakaretso ka har'a meeli e amohelehang.Litlamorao tse ka sehloohong tse mpe tsa tsamaiso ea molomo li kenyelletsa boima ba 'mele le edema ea maoto e tlase e bakoang ke ho boloka metsi le sodium, palpitation le arrhythmia e bakoang ke reflex sympathetic nerve excitation, le hirsuism.Litlamorao tse mpe tse ka sehloohong tsa litokisetso tsa lihlooho e ne e le ho hlohlona ha letlalo, erythema, pruritus le litlamorao tse ling tsa dermatitis.Le hoja palo ea ho kenngoa ha litokiso tsa lihlooho e nyenyane haholo, e ke ke ea qojoa hore e ka ba le phello ho boemo ba bakuli ba nang le histori ea lefu la pelo.Bakuli ba nang le lefu la cerebrovascular, lefu la pelo le sa bakoeng ke khatello ea mali, lefu la pelo, angina pectoris, infarction ea myocardial, effusion ea pericardial, ho se sebetse hantle ha renal le mafu a mang, bakuli ba minoxidil allergy le pheochromocytoma ba lokela ho haneloa.
Nako ea poso: Jan-06-2023