Lihlahisoa tsa limela tsa tlhaho CAS 51-34-3 Scopolamine
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Litaba tsa Motheo
Scopolamine(hyoscine) e fumaneha ho litho tse fapaneng tsa Solanaceae (mohlala, H. niger, Duboisia myoporoides, Scopolia spp., le Datura metel).Hangata Scopolamine e qheleloa ka thoko ho joala ba 'm'a bo setseng ho itšehla thajana ho hyoscyamine.
Hyoscine ke lebitso la khale la alkaloid ena, le hoja scopolamine ke lebitso le amohelehang United States.Scopolamine ke karolo ea levo ea motsoako oa racemic o tsejoang e le atrosine.Alkaloid e rarolloa habonolo ka boteng ba alkali e hlapollang.
Alkaloid e hlaha ka sebopeho sa levorotatory, viscousliquid e qhibilihang hanyane feela metsing empa e qhibiliha haholo ka joala, chloroform kapa ether.E etsa matsoai a kristale ka li-acid tse ngata, 'me hydrobromide ke eona e tsitsitseng le e amoheloang ka ho fetisisa.Tharollo e nang le metsi ea hydrobromide e nang le 10% ea mannitol ho boleloa hore ha e na mokhoa oa ho bola ho feta tharollo e sa sireletsehang.
Pharmacology
Scopolamine butylbromide, scopolamine e fetotsoeng, ke sethethefatsi sa peripheral anti-choline;ha se feela hore e ka boreleli mesifa empa hape e thibela ganglion le neuromuscular junction mme e na le phello e fokolang bohareng.Setlhare sena se na le liphello tse matla ho mala a boreleli a mesifa ho feta atropine le anisodamine;e ka ikhethela ho imolla lesapo la mala, lesapo la biliary, le mosehla o boreleli oa mesifa le ho thibela ho tsikitla ha eona.
Scopolamine butylbromide e na le litlamorao tse fokolang pelong, seithuti le tšoelesa ea mathe, ka hona ha se hangata e bakang thabo e kholo ea methapo ea kutlo, ho atoloha, ho thibela ho tsoa ha mathe, le litlamorao tse ling tse mpe, tse fapaneng le atropine.
Scopolamine butylbromide ke mohanyetsi oa M cholinergic receptor, liphello tsa eona tsa meriana li tšoana le atropine, empa e na le litšobotsi tsa eona tse nang le molemo o hlakileng oa ho ntlafatsa microcirculation ea mali.
Tšebeliso
1. Scopolaminee sebelisetsoa hoo e batlang e le matšoao a tšoanang le a atropine, empa hoa lokela ho hlokomeloa hore e na le phello ea sedative mosebetsing oa motlakase, 'me e buelloa bakeng sa phekolo ea matšoao a Parkinsonian.
2. cholinergic (ophthalmic).