JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3
Ikopanye le 'na
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Tšebeliso
JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO kapa AM-678) ke k'hemik'hale ea analgesic lelapeng la naphthoyl indole, e hlahisoang ho CB 1 le CB 2 cannabinoid receptors, E na le tse itseng. selectivity bakeng sa CB 2. E hlahisa liphello ho liphoofolo tse tšoanang le THC, cannabinoid e fumanoang ka tlhaho ka har'a cannabis, e lebisang tšebelisong ea eona ho lihlahisoa tsa li-cannabis tsa maiketsetso, tseo linaheng tse ling li rekisoang ka molao e le "monko o monate".
Joaloka agonist e feletseng bakeng sa CB 1 le CB 2 cannabinoid receptors, motsoako ona o khetholloa e le analgesic.Litlamorao tsa analgesic tsa cannabinoid ligands tse kenelletseng ke li-receptor tsa CB1 li bonahetse hantle kalafong ea bohloko ba neuropathic, bohloko ba mofets'e le ramatiki.
Metsoako ena e sebetsa ka ho etsisa lihomone tsa 'mele tsa endocannabinoid tse hlahang ka tlhaho, joalo ka 2-AG le anandamide (AEA), tse sebetsang ka tlhaho mme li ka matlafatsa kapa tsa thibela matšoao a methapo.Hobane ha ho tsejoe hakaalo ka lisosa tsa linaha tsa bohloko bo sa foleng, lipatlisiso tse eketsehileng le tsoelo-pele li tlameha ho etsoa pele matla a phekolo ea metsoako e joalo ea likokoana-hloko e ka phethahala.
Litlhaloso
Nomoro ea CAS | 29622-29-5 | Lebitso le tloaelehileng | RAD 150 |
Density | 1.088g/cm3 | Bntlha ea mafura | 424.5ºC ho 760mmHg |
Mmokhoa oa olecular | C16H25ClN2Or | Mboima ba olecular | 296.83600 |
PSA | 35.83000 | Fntlha ya lehlapa | 210.5ºC |