Human Choroinic Gonadotrophin HCG CAS:9002-61-3

Human chorionic gonadotropin (hCG) ke hormone ea glycoprotein e hlahisoang ke lisele tsa placental endodermal.Mosebetsi oa eona o ka sehloohong ke ho susumetsa corpus luteum, e leng se loketseng ho tsoela pele ho hlahisa estrogen le progesterone, e le ho khothalletsa ho thehoa ha popelo e fokolang le ho etsa hore placenta e hōle le ho hōla.Hang ha lesea le sa tsoa emoloa le kenngoa, lisele tsa blastoderm li qala ho hlahisa hCG, kahoo bokhachane bo ka khethoa ke litekanyetso tsa hCG maling kapa morotong.

E ne e entsoe ka mesaletsa ea 244 ea amino acid, e nang le boima ba molek'hule ea 36.7kDa le boholo ba 7.5 × 3.5 × 3 nm.Ke heterodimer e nang le α subunit e tšoanang le luteinizing hormone (LH), follicle-stimulating hormone (FSH) le thyrotropin (TSH), empa e fapaneng β subunit.Karolo ea α e ne e e-na le masalla a 92 a amino acid, 'me karoloana ea β e ne e e-na le masalla a 145 a amino acid.

Tšimoloho ea hCG ho basali e eketseha haholo ka mor'a kemolo, 'me ho ba teng ha hCG ka plasma le moroto ke e' ngoe ea matšoao a pele a bokhachane 'me e sebelisetsoa tlhahlobo ea bokhachane.

(1) E na le mosebetsi oa FSH le LH ho boloka nako ea bophelo ea ho ilela khoeli corpus luteum le ho etsa hore menstrual corpus luteum e be gestational corpus luteum;

(2) Khothaletsa monko o monate oa androgens ho estrogen, le ho susumetsa sebopeho sa progesterone;

(3) Ho thibela phello ea ts'usumetso ea semela sa lectin ho lymphocyte, gonadotropin ea chorionic ea motho e ka adsorbed holim'a lisele tsa trophoblast, e le ho qoba tlhaselo ea lisele tsa embryonic trophoblast ke li-lymphocyte tsa 'mè;

(4) LH tshebetso, pele pituitary ea fetal e ntša LH, e susumelletsa testis ea fetal ho ntša testosterone ho khothalletsa phapang ea banna;E ka boela ea khothalletsa tsoelo-pele ea gonadal, e motona e ka susumetsa matla a lisele tsa testis mesenchymal, ea eketsa secretion ea hormone ea banna (testosterone).Ke ea bohlokoa haholo bakeng sa phekolo ea bakuli ba banna ba nang le bokooa ba pituitary, e ke keng ea khothalletsa tsoelo-pele ea gonad le secretion ea li-hormone tsa banna, empa hape e khothalletsa nts'etsopele ea litšobotsi tsa bobeli tsa thobalano.

(5) E ka tlama mokelikeli oa TSH oa lisele tsa qoqotho ea 'mè le ho susumetsa mosebetsi oa qoqotho.