GW-0742 SARMs Phofo |GW610742 CAS 317318-84-6
Tšebeliso
Bakeng sa botenya, lefu la tsoekere, dyslipidemia le lefu la pelo Setlhare sa liteko se reretsoeng ho laola lipids le ho eketsa boemo ba HDL, kapa k'holeseterole e ntle, maling.Motsoako oa thiazolyl o kenang ka sele, o sebetsang joalo ka matla, kamano e phahameng, PPARδ agonist.E bonts'a khetho ea PPARδ ha e bapisoa le PPARα le PPARγ.Ha e tsoe tšebetsong efe kapa efe khahlano le li-receptor tse ling tsa nyutlelie kapa tseo e seng tsa nyutlelie.Ho tlalehiloe ho eketsa cholesterol efflux le polelo ea ABAC1 ho macrophages, fibroblasts le lisele tsa mala.
Cardarine e sebelisoa ke baatlelete ba hlōlisanang lipapaling tse ngata tse fapaneng.Ka mohlala, baatlelete ba mamello ba ka eketsa mamello ea boikoetliso ka ho kenya PPAR ena le lithethefatsi tsa analoge tsa AMP AICAR, kapa ho matha cardarine solo.Ka lebaka leo, ba tla ba le bokhoni bo boholo ba ho fihlela li-RPM tse phahameng ha ba ntse ba matha ntle le ho otla lebelo le phahameng la pelo.Sena se tla lumella semathi / mopalami oa libaesekele / sesesi ho qhekella lebelo la bona la pelo le ho tsamaea nako e telele ntle le moea, ho etsa hore stack ena e be sebetsa se makatsang se ka sebelisoang lipapaling tsa mamello.Ha e le hantle, ho tsoa phihlelong ea botho nka bolela hore cardarine e ka kokota ka metsotsoana ea 30-45 ka nako ea 5K haeba e sebelisoa ho lebisa peisong.
Tlhaloso
MANTSOE A BOHLOKOA: Ho lahleheloa ke mafura, ho ntlafatsa mamello, ha ho na litla-morao, sehahi sa 'mele, pheko ea botenya hammoho le ho thusa ho boloka boima ba 'mele, ho eketsa boima ba mesifa.
Cardarine (GW-501516) e arotsoe ka sehlopha sa SARMS, leha ho le joalo ka sebopeho le tlhaloso, ke modulator ea PPAR.Joalo ka modulator ea PPAR, e etsa hore protheine kinase e kenngoeng ke AMP e sebetse 'me e etsa hore tsoekere e kene ka har'a mesifa ea masapo.GW-501516 e na le bokhoni ba ho fetola mathata a metabolism ka ho susumetsa mafura a acid oxidation.E nkoa e le phekolo e matla bakeng sa botenya le maemo a mang a amanang le eona.
GW501516 ke lebitso la moriana oa Glaxo Wellcome (GW e emetse khamphani mme palo ke ea sehlahisoa).E boetse e tsejoa e le GW-501,516, GW1516, GSK-516).Ke PPARδ receptor agonist e sa kang ea nkoa ho feta liteko tsa tleliniki.Ka hona e thibetsoe lipapaling.E lumellana le libaka tse 'maloa lethathamong, ho kenyeletsoa ka ho hlaka e le "a-agonists a "peroxisome Proliferator Activated Receptor δ (PPARδ) (mohlala GW501516)".Empa e tla boela e kene tlas'a karolo e ncha ea WADA ea ho tšoasa "lintho tse sa lumelloeng" tse ikemiselitseng ho emisa sethethefatsi se seng le se seng se se nang tumello se sebelisoang ke baatlelete.
GW501516 (eo hape e tsejoang e le GW-501,516, GW1516, GSK-516) ke PPAR & receptor agonist e qapiloeng ka tšebelisano pakeng tsa Ligand Pharmaceuticals le GlaxoSmithKline lilemong tsa bo-1990, e kentsoe ntlafatsong ea bongaka e le moemeli oa lithethefatsi bakeng sa mafu a metabolic le lefu la pelo. , 'me e lahliloe ka 2007 hobane tlhahlobo ea liphoofolo e bontšitse hore lithethefatsi li entse hore kankere e hlahe ka potlako lithong tse' maloa.
Phuputsong ea 2007 e ile ea hatisoa e bontša hore litekanyetso tse phahameng tsa GW501516 tse fuoeng litoeba li ntlafalitse haholo ts'ebetso ea tsona ea 'mele;mosebetsi ona o ile oa buisanoa haholo mecheng ea litaba e tsebahalang, 'me o ile oa lebisa' marakeng o mobe bakeng sa mokhethoa oa lithethefatsi le ho hlekefetsoa ha oona ke baatlelete e le moemeli oa doping.
Lisebelisoa
GW501516 e ne e ka sebelisoa ke baatlelete e le lithethefatsi tse matlafatsang ts'ebetso ea ergogenic eo hona joale e neng e sa laoloe ke melao kapa e fumanoe ka liteko tse tloaelehileng.E mong oa bafuputsi ba ka sehloohong ba thuto e mabapi le mamello e ntlafetseng ka lebaka leo o ile a etsa tlhahlobo ea moroto ho bona sethethefatsi sena, 'me a etsa hore se fumanehe ho Komiti ea Machaba ea Liolimpiki.
GW e hlohlelletsa ho kenngoa ha tsoekere le mesifa ea masapo.E chesa mafura ka ho susumetsa mafura a acid oxidation.E khothaletsoa e le pheko e ka bang teng bakeng sa botenya ka lebaka la bokhoni ba eona ba ho qhibilihisa mafura ka potlako.Hape, ho boleloa hore Cardarine e eketsa HDL ka karolelano ea 79% (cholesterol e ntle) le ho fokotsa LDL (cholesterol e mpe) litekong tsa hona joale tsa Phase II.GW 501516 ke agonist ea PPARδ.Tsena li thusa ho eketsa maemo a HDL ho tsoa polelong e ntlafalitsoeng ea sepalangoang sa k'holeseterole ABCA1.
GW e hlohlelletsa ho kenngoa ha tsoekere le mesifa ea masapo.E chesa mafura ka ho susumetsa mafura a acid oxidation.E khothaletsoa e le pheko e ka bang teng bakeng sa botenya ka lebaka la bokhoni ba eona ba ho qhibilihisa mafura ka potlako.Hape, ho boleloa hore Cardarine e eketsa HDL ka karolelano ea 79% (cholesterol e ntle) le ho fokotsa LDL (cholesterol e mpe) litekong tsa hona joale tsa Phase II.GW 501516 ke agonist ea PPARδ.Tsena li thusa ho eketsa maemo a HDL ho tsoa polelong e ntlafalitsoeng ea sepalangoang sa k'holeseterole ABCA1.
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