Glucagon CAS: 16941-32-5 Glucagon(1-29) Motho HCl GLUCAGON 1-37

Glucagon, eo hape e tsejoang e le hyperglycemin le glucagon, ke hormone ea polypeptide e otlolohileng e hlahisoang ke lisele tsa α tsa pancreatic islet, tse nang le 29 amino acid.Mokhoa oa eona oa limolek'hule le boima ba 'mele oa molek'hule ke C153H225N43O49S=3482.8.Hormone ena e entsoe naheng ea heso.Phofo e tšoeu e ntle ea kristale mocheso oa kamore, e sa nkheng, e sa latsoeheng.Ha e qhibilihe ka metsing le ka bongata ba lihlapolli tsa lintho tse phelang, tse qhibilihang ka asiti e hlapollang le ho hlapolla lye.Litokisetso tse ngata li entsoe ka hydrochloride ea eona, e qhibilihang ka metsing.Hona joale hoa tsebahala hore glucagon e tlameha ho boloka bots'epehi ba eona ba limolek'hule e le hore e tsebe ho sebelisa tšebetso ea eona ea 'mele.Sebopeho sa hyperglycemic se ka 'na sa lumellana le batho le liphoofolo tse anyesang (mebutla, likhomo, likolobe, likhoto, joalo-joalo), empa li fapane hanyane ho linonyana.Ke hormone ea bohlokoa ho boloka tsoekere e tloaelehileng ea mali.Mosebetsi oa eona o ka sehloohong ke ho kenya tšebetsong phosphorylase ho myocardium, ho khothaletsa ho bola ha glycogen le ho ba le litlamorao tse kang catecholamin.Ka hona, e na le phello e matla ea pelo ho pelo, e eketsa lebelo la pelo, ho fokotseha ha myocardial le ho phalla ha mali.Cardioenhancement ha e tsamaee le ho eketseha ha thabo ea pelo, empa e eketsa li-ion tsa calcium ho cardiomyocytes 'me e ka etsa hore adenosine cyclase e sebetse ka lera la lisele tsa sebete ho Chemicalbook, e khothalletsang ho qaptjoa ha cyclic adenosine phosphate liseleng.Ho tlalehiloe hore glucagon e sebetsa maemong a mang a lefu la pelo.Ho feta moo, maemo a plasma a boetse a eketsehile ho ea ho maemo a fapaneng a lefu la tsoekere, lefu la sebete, lefu la liphio, hlahala ea glucagon le khatello ea maikutlo.Glucagon e na le mesebetsi e mene ea fisioloji ea ho khothaletsa glycogenolysis ea sebete, glycogenogenesis ea sebete, lipolysis le sebopeho sa 'mele oa ketone.E ka khothaletsa ho amoheloa ha li-amino acid liseleng tsa sebete, ea potlakisa ts'ebetso ea deamination ea li-amino acid sebeteng, ea fokotsa bongata ba li-amino acid ka plasma, ea fokotsa motsoako oa protheine le ho khothaletsa sebete glycogenogenesis.Ho feta moo, e ka boela ea kenya tšebetsong matla a lipase a lisele tsa polokelo ea lipid ea sebete, ea eketsa ho lokolloa ha mafura a mafura a mahala, ea potlakisa ts'ebetso ea lipoic acid oxidation ea lisele tsa sebete, 'me ea eketsa tlhahiso ea sebete sa glyccoconeogenesis le' mele oa ketone.Ka nako e ts'oanang, glucagon e ka thibela tsitsipano le peristalsis ea mpa, mala a manyane le colon, ea fokotsa tsitsipano ea gallbladder, ea thibela pancreatic exocrine, 'me ea thibela ho kenngoa ha metsi le letsoai ka intestinal mucosa.Litekanyetso tse kholo tsa glucagon le tsona li ka eketsa khatello ea cAMP liseleng tsa myocardial, tsa eketsa lebelo la pelo le ho ntlafatsa ho hlaka ha myocardial.