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Exendin-4 CAS 141758-74-9 Exenatide Acetate Salt Exenatide

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  • Lebitso le tloaelehileng:Exendin-4
  • Nomoro ea CAS:141758-74-9
  • Foromo ea molek'hule:Setšoantšo sa C184H282N50O60S
  • Boima ba molek'hule:4186.57188
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    Sebopeho:

    Lebitso le tloaelehileng Exenatide Lebitso la Senyesemane Exenatide letsoai la acetate
    Nomoro ea CAS 141758-74-9
    Mokhoa oa limolek'hule Setšoantšo sa C184H282N50O60S
    Boima ba molek'hule 4186.57000
    Boima bo nepahetseng 4184.03000
    PSA 1775.05000
    Maemo a polokelo E tiisitsoe, boloka ho -20ºC
    Botsitso Ha ho na ho bola, ha ho na likarabelo tse kotsi tse tsejoang haeba li sebelisoa le ho bolokoa ho latela litlhaloso

     

    Tšebeliso:

    Exenatide ke setlhare sa pele sehlopheng se secha sa antidiabetics se tsejoang e le incretin mimetics, 'me se bontšoa e le kalafo e tlatselletsang ho ntlafatsa taolo ea glycemic ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 ba nkang metformin, sulfonylurea kapa ka bobeli, empa e fihletse taolo e lekaneng ea glycemic.Exenatide ke analogue e sebetsang ea incretin ea motho ea Glucagon-Like Peptide-1 (GLP-1).GLP-1 ka tlhaho e lokolloa liseleng tsa pampitšana ea GI ka lebaka la ho ja lijo 'me e sebetsa ho li-receptor tsa eona ho lisele tsa b ho matlafatsa secretion ea insulin e susumetsoang ke tsoekere.Exenatide ke agonist ea nako e telele ho li-receptor tsa GLP-1.Ke mofuta oa maiketsetso oa peptide ea 39-amino acid e fumanoang ka har'a mathe a phoofolo ea tonanahali ea Gila.hape e leka-lekaneng maemo a phahameng a serum glucagon nakong ea linako tsa hyperglycemic ka mor'a lijo, empa ha e kena-kenane le ho lokolloa ha glucagon ho arabela hypoglycemia.Tekanyetso ea litekanyetso tsa exenatide ke 5 kapa 10 mg habeli ka letsatsi, e tsamaisoa e le ente ea subcutaneous nakong ea hora pele ho lijo tsa hoseng le tsa mantsiboea.Kamora ho tsamaisoa ka subcutaneous, khatello e phahameng ea plasma ea exenatide e fihlella ka mor'a lihora tse 2.1, 'me profil ea pharmacokinetic ea plasma e lekana.Liketsahalo tse mpe tse tlalehiloeng ka exenatide li kenyelletsa ho nyekeloa ke pelo, ho hlatsa, letšollo, ho tsieleha, ho tsekela, hlooho, le dyspepsia.

    Exendin-4 e ka kenya tšebetsong receptor ea GLP-1, receptor e ka eketsa maemo a cAMP a lisele tsa pancreatic acinar ka har'a intracellular, empa ha e na phello ho VIP receptor.

    Exendin-4 e 'nile ea sebelisoa e le incretin mimetics bakeng sa phekolo ea lisele tsa HepG2 ho kenyelletsa tšusumetso ea lisebelisoa tse thusang.E boetse e sebelisitsoe e le agonist ea r (GLP-1R) ho kenyelletsa tšitiso ea thepa e thusang.

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